The Haight-Ashbury Free Clinic is the most popular drug treatment program in the San Francisco Bay Area, with about 1300 heroin abusers and 1700 stimulant (cocaine or methamphetamine) abusers seeking treatment annually. Because of parenteral and/or sexual practices, most of these persons are at high risk for HIV infection. We propose to enroll about 20% of this clientele in a controlled study of two key interventions: (1) medications to control """"""""craving"""""""" (tricyclic antidepressants or amino acid precursors for stimulants, naltrexone for heroin) and (2) behavioral training to shape and reinforce safer sexual and parenteral practices. Four groups (N=154 each) of S's will receive neither, either, or both of these interventions in a 2 x 2 research design. Outcome measures will include behavioral assessment, psychological functioning, and HIV seroprevalence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Demonstration and Dissemination Projects (R18)
Project #
1R18DA006145-01
Application #
3441673
Study Section
(SRCD)
Project Start
1989-09-30
Project End
1992-08-31
Budget Start
1989-09-30
Budget End
1990-08-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Haight-Ashbury Free Clinics, Inc.
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94129
Galloway, G P; Newmeyer, J; Knapp, T et al. (1996) A controlled trial of imipramine for the treatment of methamphetamine dependence. J Subst Abuse Treat 13:493-7