The keystone of health services research is availability of large databases. Data from single state Medicaid programs have been fruitfully exploited in the past. A recent HCFA research initiative is resulting in a massive multistate Medicaid database encompassing a population of 10 million over a three year period. This research proposes to develop health services research methodology to use the database for monitoring drug safety. A particular focus is upon drug utilization review for drugs which cause adverse reactions not detected by extant monitoring systems. The development of methodology will be achieved through a series of seven specific drug substudies utilizing the multistate database. A second series of six substudieds will monitor the safety of several controversial drugs, improving our understanding of the risks and benefits of these drugs. A final objective in promotion of health services research, which, at low marginal cost, can exploit a massive existing database.
| Ray, W A; Griffin, M R (1989) Use of Medicaid data for pharmacoepidemiology. Am J Epidemiol 129:837-49 |
| Griffin, M R; Ray, W A; Schaffner, W (1988) Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Ann Intern Med 109:359-63 |
| Griffin, M R; Ray, W A; Livengood, J R et al. (1988) Risk of sudden infant death syndrome after immunization with the diphtheria-tetanus-pertussis vaccine. N Engl J Med 319:618-23 |
| Griffin, M R; Ray, W A; Fought, R L et al. (1988) Monitoring the safety of childhood immunizations: methods of linking and augmenting computerized data bases for epidemiologic studies. Am J Prev Med 4:5-13 |
