Abstract

The overall goal of the project is to identify mechanisms that regulate the initiation and progression of age-related thymic involution, which will allow the development of novel interventions for immune reconstitution in HIV-infected patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21AG016826-01
Application #
2848255
Study Section
Special Emphasis Panel (ZRG5-AARR-2 (03))
Project Start
1998-09-30
Project End
2000-09-29
Budget Start
1998-09-30
Budget End
1999-09-29
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Pathology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Hale, Laura P (2002) Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes. J Invest Dermatol 119:464-70
Flores, Kristina G; McAllister, Kimberly A; Greer, Paula K et al. (2002) Thymic model for examining BRCA2 expression and function. Mol Carcinog 35:103-9
Hale, L P; Price, D T; Sanchez, L M et al. (2001) Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer. Clin Cancer Res 7:846-53
Hale, L P; Clark, A G; Li, J et al. (2001) Age-related thymic atrophy in the guinea pig. Dev Comp Immunol 25:509-18
Flores, K G; Li, J; Hale, L P (2001) B cells in epithelial and perivascular compartments of human adult thymus. Hum Pathol 32:926-34
Markert, M L; Alvarez-McLeod, A P; Sempowski, G D et al. (2001) Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy. AIDS Res Hum Retroviruses 17:1635-43
Collard, H R; Boeck, A; Mc Laughlin, T M et al. (1999) Possible extrathymic development of nonfunctional T cells in a patient with complete DiGeorge syndrome. Clin Immunol 91:156-62
Flores, K G; Li, J; Sempowski, G D et al. (1999) Analysis of the human thymic perivascular space during aging. J Clin Invest 104:1031-9
Haynes, B F; Hale, L P (1998) The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. Immunol Res 18:61-78
Haynes, B F; Hale, L P (1998) The human thymus. A chimeric organ comprised of central and peripheral lymphoid components. Immunol Res 18:175-92