? Hearing deficits are the third leading cause of disability in the aged. Over half of all people in the US over seventy suffer some form of age-related hearing deficits. This is a ubiquitous problem with many sources, and the peripheral contributions to age-related deficits, particularly high frequency hearing loss, have been explored and have revealed several important features of these disorders. However, there remains relatively little understood about the consequences of age-related hearing loss and normal aging on central auditory structures, particularly the neocortex, and how age-related changes in either anatomical or physiological processes in central structures give rise to perceptual deficits. Our lack of understanding of these central effects is due in large part to the lack of an effective animal model that (1) shares many organizational features of auditory cortex with humans, (2) has a reasonably long life span such that age-related hearing deficits progress over the course of several years as in the human, and (3) are not prohibitively expensive. I have a unique opportunity to develop such an animal model as I have access to a large geriatric colony of macaque monkeys that satisfy these three criteria. The goals of this proposal are to determine which auditory cortical response properties are most influenced by normal aging and age-related hearing loss. Two normal young animals, two older animals with age- related high frequency hearing loss, and two older age-matched animals without age-related hearing loss will be used in these experiments. Spectral, spatial, and temporal response properties of single neurons in primary and secondary auditory cortical fields will be defined in each, monkey. Comparisons between neurons in different monkeys, as well as in auditory cortical fields that have been reorganized due to the high frequency hearing loss, will be compared to determine which aspects of auditory information processing are most susceptible to aging and age-related hearing loss. The results of this study will provide the foundation for future research programs aimed at the development of remedial treatments and therapies, as well as in hearing aid design, for individuals suffering from age-related hearing deficits. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21AG024372-01A1
Application #
7049149
Study Section
Auditory System Study Section (AUD)
Program Officer
Monjan, Andrew A
Project Start
2006-08-15
Project End
2008-07-31
Budget Start
2006-08-15
Budget End
2007-07-31
Support Year
1
Fiscal Year
2006
Total Cost
$161,013
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Arts and Sciences
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Recanzone, Gregg (2018) The effects of aging on auditory cortical function. Hear Res 366:99-105
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Gray, Daniel T; Engle, James R; Recanzone, Gregg H (2014) Age-related neurochemical changes in the rhesus macaque superior olivary complex. J Comp Neurol 522:573-91
Gray, Daniel T; Engle, James R; Recanzone, Gregg H (2014) Age-related neurochemical changes in the rhesus macaque cochlear nucleus. J Comp Neurol 522:1527-41
Engle, James R; Tinling, Steve; Recanzone, Gregg H (2013) Age-related hearing loss in rhesus monkeys is correlated with cochlear histopathologies. PLoS One 8:e55092
Gray, Daniel T; Rudolph, Megan L; Engle, James R et al. (2013) Parvalbumin increases in the medial and lateral geniculate nuclei of aged rhesus macaques. Front Aging Neurosci 5:69
Recanzone, Gregg H; Engle, James R; Juarez-Salinas, Dina L (2011) Spatial and temporal processing of single auditory cortical neurons and populations of neurons in the macaque monkey. Hear Res 271:115-22
Juarez-Salinas, Dina L; Engle, James R; Navarro, Xochi O et al. (2010) Hierarchical and serial processing in the spatial auditory cortical pathway is degraded by natural aging. J Neurosci 30:14795-804
Recanzone, Gregg H; Cohen, Yale E (2010) Serial and parallel processing in the primate auditory cortex revisited. Behav Brain Res 206:1-7
Miller, Lee M; Recanzone, Gregg H (2009) Populations of auditory cortical neurons can accurately encode acoustic space across stimulus intensity. Proc Natl Acad Sci U S A 106:5931-5

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