Vitamin D has a critical role in bone mineral homeostasis but also has a broad range of other physiological effects. Deficiency of 25-hydroxyvitamin D, the major circulating form, is associated with increased risk of age-related chronic conditions including Alzheimer's disease, Parkinson's disease, cognitive impairment and a wide range of cancers. However, the mechanism that links vitamin D deficiency to diverse chronic diseases is unknown but it is suspected that elderly populations are vitamin D deficient. We have discovered that exposure of adult Caenorhabditis elegans (C. elegans) to D3 prevented the accumulation of a diverse range of insoluble proteins during aging and extended lifespan. It also prevents the aggregation of Abeta peptide. We have preliminary data that suggests that these beneficial effects require the endoplasmic reticulum unfolded protein response (ER UPR) and a nuclear hormone receptor (NHR-226) which may be acting as a vitamin D receptor.
We aim to uncover the mechanism at play with a view to understanding the role played by vitamin D in human health. We propose to establish whether the effects of vitamin D are through a nuclear or a non-nuclear mechanism and establish how vitamin is affecting protein homeostasis. To do so, we must first understand vitamin D metabolism in C. elegans so we can manipulate vitamin D action. We expect our results could be influential how vitamin D is studied in relation to human chronic disease.

Public Health Relevance

There is considerable debate about how much vitamin D supplements we should all be taking with some experts believing just about everyone over 65 is vitamin D deficient. If this is true, then it is a major public health issue because low vitamin D levels are associated with everything from cancer to Alzheimer's and Parkinson's disease. We have discovered that vitamin D slows aging and a pathology associated with neurodegeneration in a simple animal model;now we propose to understand the mechanism at play.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Exploratory/Developmental Grants (R21)
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Cellular Mechanisms in Aging and Development Study Section (CMAD)
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Finkelstein, David B
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Buck Institute for Age Research
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Lucanic, Mark; Plummer, W Todd; Chen, Esteban et al. (2017) Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects. Nat Commun 8:14256
Mark, Karla A; Dumas, Kathleen J; Bhaumik, Dipa et al. (2016) Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep 17:1227-1237