Approximately 60,000 new cases of Parkinson's disease are diagnosed each year in the US. Parkinson's disease is second in prevalence only to Alzheimer's disease among neurodegenerative disorders, and causes untold anguish to patients and their families, and costs patients and society billions of dollars per year. To facilitate better understanding of Parkinson's disease, the Michael J. Fox Foundation has sponsored The Parkinson Progression Marker Initiative. Toward this end, study evaluates hundreds of normal and Parkinson's subjects, and collects biological samples and MR images, and makes these data freely available to researchers. We propose to apply sophisticated methods for analyzing complex, large data sets to these data, to help researchers understand the underlying changes in genes and brain structure in patients in Parkinson's disease. We also propose to apply robust methods for automatically detecting subtypes among people with Parkinson's disease, based on brain connectivity as revealed by MRI, or by genetic differences. We expect that these differences will indicate differing prognosis, and perhaps point toward promising treatments.

Public Health Relevance

Parkinson's disease researchers have access to sophisticated data from normal subjects, and people with Parkinson's disease. However, powerful methods for analyzing genetic, clinical and MRI data do not exist. We propose to develop an integrated application for the analysis of these data, in the hope of fostering better understanding of Parkinson's disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Exploratory/Developmental Grants (R21)
Project #
3R21AG058118-02S1
Application #
9837536
Study Section
Biodata Management and Analysis Study Section (BDMA)
Program Officer
St Hillaire-Clarke, Coryse
Project Start
2018-06-15
Project End
2021-05-31
Budget Start
2019-06-15
Budget End
2021-05-31
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201