Long non-coding RNAs (lncRNAs) have recently emerged as a key level of regulation and complexity in innate immunity through many different mechanisms ranging from activating or repressing NF-kB signaling, regulating TLR signaling, and altering chromatin modifications. Using a combination of an in silico computational platform, together with rational experimental perturbations, we have identified lncRNA ZFAS1 and its SNORDs as putative regulators of cytosolic sensing on nucleic acids. We seek to further characterize the roles and functions of the ncRNAs both in vitro and in vivo contexts of viral infection and nucleic acid sensing.
