We describe in this application detailed plans for the enhancement of prostate cancer research at the University of Iowa. Prostate cancer is the second leading cause of death among males in the United States. Since 1992 the Principal Investigator has Co-Directed a Prostate Cancer Research Group that serves as the foundation for the organization of the proposed Prostate Cancer Program addressed in this application. To support such a program we describe a significant commitment from a number of important offices within the administration of the University of Iowa. The program will include a planning and evaluation process for funding pilot/feasibility projects in prostate cancer and the generation of new ideas and subsequent funding. Eventually the data obtained from the funded projects will compete successfully for larger extramural grants, such as NIH R01s. An integral part of this application is a description of five pilot/feasibility projects in the areas that represent research strengths at this institution. Each project is the result of collaborations among members of different departments and programs at Iowa. The areas covered by these projects include epidemiology, chemoprevention, immunotherapy, gene therapy, and clinical studies. We also describe the need to recruit new investigators into the University of Iowa's Prostate Cancer Research Group. Plans to carry out this recruitment involve significant commitments from the University of Iowa Cancer Center and from the Department of Urology. Both will share the cost for recruitment, salary, and supplies with the grant funds. The successful development of a Prostate Cancer Program at the University of Iowa will permit continued research into the basic mechanisms involved in the development, prevention, and treatment of prostate cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21CA069838-04
Application #
2769841
Study Section
Special Emphasis Panel (SRC (06))
Program Officer
Holmes, Margaret E
Project Start
1995-09-30
Project End
2000-08-31
Budget Start
1998-09-01
Budget End
2000-08-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Iowa
Department
Urology
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Putnam, S D; Cerhan, J R; Parker, A S et al. (2000) Lifestyle and anthropometric risk factors for prostate cancer in a cohort of Iowa men. Ann Epidemiol 10:361-9
Parker, A S; Cerhan, J R; Putnam, S D et al. (1999) A cohort study of farming and risk of prostate cancer in Iowa. Epidemiology 10:452-5
Cerhan, J R; Parker, A S; Putnam, S D et al. (1999) Family history and prostate cancer risk in a population-based cohort of Iowa men. Cancer Epidemiol Biomarkers Prev 8:53-60
Robbins, M; Ali, K; McCaw, R et al. (1999) gamma-linolenic acid (GLA)-mediated cytotoxicity in human prostate cancer cells. Adv Exp Med Biol 469:499-504
Luo, J; Lubaroff, D M; Hendrix, M J (1999) Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection. Cancer Res 59:3552-6
Cerhan, J R; Pavuk, M; Wallace, R B (1999) Positive association between resting pulse and cancer incidence in current and former smokers. Ann Epidemiol 9:34-44
Cerhan, J R; Cantor, K P; Williamson, K et al. (1998) Cancer mortality among Iowa farmers: recent results, time trends, and lifestyle factors (United States). Cancer Causes Control 9:311-9
Flanagan, S W; Moseley, P L; Buettner, G R (1998) Increased flux of free radicals in cells subjected to hyperthermia: detection by electron paramagnetic resonance spin trapping. FEBS Lett 431:285-6
Baker, A M; Oberley, L W; Cohen, M B (1997) Expression of antioxidant enzymes in human prostatic adenocarcinoma. Prostate 32:229-33
Cerhan, J R; Torner, J C; Lynch, C F et al. (1997) Association of smoking, body mass, and physical activity with risk of prostate cancer in the Iowa 65+ Rural Health Study (United States). Cancer Causes Control 8:229-38