Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21CA070790-01
Application #
2114596
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1996-05-21
Project End
1998-04-30
Budget Start
1996-05-21
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Su, Meng; Alonso, Salvador; Jones, Jace W et al. (2015) All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment. PLoS One 10:e0127790
Ghiaur, Gabriel; Yegnasubramanian, Srinivasan; Perkins, Brandy et al. (2013) Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling. Proc Natl Acad Sci U S A 110:16121-6
Ghiaur, Gabriel; Gerber, Jonathan; Jones, Richard J (2012) Concise review: Cancer stem cells and minimal residual disease. Stem Cells 30:89-93
Ghiaur, Gabriel; Gerber, Jonathan M; Matsui, William et al. (2012) Cancer stem cells: relevance to clinical transplantation. Curr Opin Oncol 24:170-5
Bobola, Michael S; Blank, A; Berger, Mitchel S et al. (2007) O6-methylguanine-DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesis. DNA Repair (Amst) 6:1127-33
Bobola, Michael S; Finn, Laura S; Ellenbogen, Richard G et al. (2005) Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors. Clin Cancer Res 11:7405-14
Bobola, Michael S; Emond, Mary J; Blank, A et al. (2004) Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy. Clin Cancer Res 10:7875-83
Silber, John R; Bobola, Michael S; Blank, A et al. (2002) The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress. Clin Cancer Res 8:3008-18
Bobola, M S; Blank, A; Berger, M S et al. (2001) Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas. Clin Cancer Res 7:3510-8
Silber, J R; Blank, A; Bobola, M S et al. (1999) O6-methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: frequency and time to tumor progression after alkylating agent-based chemotherapy. Clin Cancer Res 5:807-14

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