In 2006, the FDA approved the first human papilloma virus (HPV) vaccine with the Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) subsequently recommending this vaccine for 9-26 year old females. The long-term objective of this research is to improve HPV vaccination rates among underage female adolescents, which we define for the purposes of this application as children between the ages of 9-17 years old. Children of this age range require parental consent to receive vaccines. Thus, we seek to determine the utility of cervical and breast cancer screening encounters in mothers to serve as teachable moments or natural gateways to improve HPV vaccination rates in their adolescent daughters. The overarching specific aim of this application is to determine the effects of low-intensity tailored interventions aimed at women undergoing breast or cervical cancer screening on their daughters'HPV vaccination rates. Methods: Women with adolescent daughters eligible for HPV vaccination will be randomized to two groups: the low intensity tailored intervention group (receiving CDC fact sheet """"""""HPV Vaccine Questions &Answers"""""""" during the cancer screening visit and a reminder letter with educational information tailored to the mother's perceptions of barriers and benefits to HPV vaccination will be sent 1 month later);and the control group (receiving usual care/no intervention). Outcome: Adolescent HPV vaccination initiation (defined as receiving at least one dose) and completion (receiving all three doses) will be evaluated at 6 and 12 months respectively, after the cancer screening visit using electronic medical records and parental surveys. Significance: This R21 feasibility grant proposes an innovative low-cost intervention to increase human papilloma virus (HPV) vaccination among adolescent females by targeting mothers undergoing routine cancer screening. Our findings have the potential to improve programs focused on adolescents for the primary prevention of cervical and other HPV-associated cancers by leveraging existing cancer control behaviors advocated by the NCI. The proposed research is well aligned with the priorities of the NCI Section on Cancer Prevention, Control, Behavioral and Population Sciences.

Public Health Relevance

Experience with human papillomavirus vaccination in adolescents is limited. This application will evaluate an innovative mechanism for potentially increasing adolescent HPV that uses maternal cancer screening encounters as educational gateways or teachable moments to improve HPV vaccinations in their adolescent daughters and will assess maternal barriers to HPV vaccinations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21CA133333-02
Application #
7943067
Study Section
Psychosocial Risk and Disease Prevention Study Section (PRDP)
Program Officer
Chollette, Veronica
Project Start
2009-09-29
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$237,930
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Bennett, Alaina T; Patel, Divya A; Carlos, Ruth C et al. (2015) Human Papillomavirus Vaccine Uptake After a Tailored, Online Educational Intervention for Female University Students: A Randomized Controlled Trial. J Womens Health (Larchmt) 24:950-7
Carlos, Ruth C; Dempsey, Amanda F; Resnicow, Ken et al. (2011) Maternal characteristics that predict a preference for mandatory adolescent HPV vaccination. Hum Vaccin 7:225-9
Carlos, Ruth C; Sadigh, Gelareh; Kelly, Aine M (2011) Women's health, accountable care organizations, and radiology practice: maximizing radiology's value under health care reform. AJR Am J Roentgenol 196:257-8
Carlos, Ruth C; Dempsey, Amanda F; Resnicow, Ken et al. (2010) Feasibility of using maternal cancer screening visits to identify adolescent girls eligible for human papillomavirus vaccination. J Womens Health (Larchmt) 19:2271-5
Carlos, Ruth C; Dempsey, Amanda F; Patel, Divya A et al. (2010) Cervical cancer prevention through human papillomavirus vaccination: using the ""teachable moment"" for educational interventions. Obstet Gynecol 115:834-8