Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder estimated to occur in approximately 10% of the United States population and, in a third of sufferers, the condition is chronic. Cigarette smoking is highly co-morbid with PTSD. Thirty-fifty percent of individuals with PTSD smoke cigarettes and are more likely to be heavy smokers. Our previous work has suggested that compared to non-PTSD smokers, context (particularly stress-related and trauma-related contexts) significantly impacts smoking craving and smoking topography in smokers with PTSD. Individuals with PTSD exhibit deficits in neurocognitive test performance, particularly in the areas of attention and memory, as well as sensorimotor gating as assessed by gating as assessed by prepulse inhibition (PPI) of the startle response. Our pilot data suggest that compared to smokers without PTSD, nicotine enhances the startle response in PTSD smokers and improves PPL What is needed now is to utilize objective measures such as startle and PPI paradigms to carefully investigate the effect of context and cigarette smoking in this high-risk psychiatric population. The overall purpose of this exploratory/developmental grant is to study the use of startle and PPI as measurement parameters for smoking and smoking withdrawal in smokers with PTSD. The proposed study will build on our previous findings and initial pilot data. Using a 2(group, PTSD versus non-PTSD) X 2(content, trauma versus neutral) X 3(smoking condition, usual brand vs. no nicotine vs. no smoking) design with varying PPI intervals, the study is designed to: a) examine the effects of acute smoking abstinence and smoking on PPI in smokers with PTSD compared to smokers without PTSD but with trauma exposure; b) evaluate the contextual effect of trauma versus neutral script presentations; c) examine the parameters of prepulse intervals on PPI over these experimental manipulations; and d) investigate possible attentional mechanisms of smoking by administering neurocognitive measures across nicotine conditions. This ultimate goal of this line of research is to inform the development of smoking cessation strategies in PTSD smokers by identifying mechanisms of smoking that may be present in smokers with PTSD. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DA019704-02
Application #
7230011
Study Section
Adult Psychopathology and Disorders of Aging Study Section (APDA)
Program Officer
Grant, Steven J
Project Start
2006-04-01
Project End
2009-01-31
Budget Start
2007-02-01
Budget End
2009-01-31
Support Year
2
Fiscal Year
2007
Total Cost
$222,736
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Volz, Angela R; Dennis, Paul A; Dennis, Michelle F et al. (2014) The role of daily hassles and distress tolerance in predicting cigarette craving during a quit attempt. Nicotine Tob Res 16:872-5
Wilson, Sarah M; Dedert, Eric A; Dennis, Paul A et al. (2014) Do ethnicity and gender moderate the influence of posttraumatic stress disorder on time to smoking lapse? Addict Behav 39:1163-7
Dedert, Eric A; Dennis, Paul A; Swinkels, Cindy M et al. (2014) Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt. Nicotine Tob Res 16:430-6
Beckham, Jean C; Calhoun, Patrick S; Dennis, Michelle F et al. (2013) Predictors of lapse in first week of smoking abstinence in PTSD and non-PTSD smokers. Nicotine Tob Res 15:1122-9
McClernon, F Joseph; Calhoun, Patrick S; Hertzberg, Jeffrey S et al. (2013) Associations between smoking and psychiatric comorbidity in U.S. Iraq- and Afghanistan-era veterans. Psychol Addict Behav 27:1182-1188
Dedert, Eric A; Elbogen, Eric B; Hauser, Michael A et al. (2012) Consumer perspectives on genetic testing for psychiatric disorders: the attitudes of veterans with posttraumatic stress disorder and their families. Genet Test Mol Biomarkers 16:1122-9
Dedert, Eric A; Calhoun, Patrick S; Harper, Leia A et al. (2012) Smoking withdrawal in smokers with and without posttraumatic stress disorder. Nicotine Tob Res 14:372-6
Calhoun, Patrick S; Levin, Holly F; Dedert, Eric A et al. (2011) The relationship between posttraumatic stress disorder and smoking outcome expectancies among U.S. military veterans who served since September 11, 2001. J Trauma Stress 24:303-8
Calhoun, Patrick S; Wagner, H Ryan; McClernon, F Joseph et al. (2011) The effect of nicotine and trauma context on acoustic startle in smokers with and without posttraumatic stress disorder. Psychopharmacology (Berl) 215:379-89
Zaborowski, Daphne E; Dedert, Eric A; Straits-Troster, Kristy et al. (2011) Public health clinical demonstration project for smoking cessation in american veterans who served since september 11, 2001. J Addict Med 5:79-83

Showing the most recent 10 out of 26 publications