This longitudinal study is designed to examine the role of biological, environmental, and psychological factors hypothesized to influence the relation between exposure to various types of violence and drug use. Participants include 400 adolescents representing two cohorts of teens living in high violence, impoverished urban areas. Latent growth curve models will be used to test specific hypotheses regarding the potential role of various factors as mediators and moderators of key variables influencing drug use in adolescents. In particular, coping processes and physiological responses to stress will be evaluated as mediators or moderator of associations between violence exposure and drug use. This home interview study is novel in that it examines both peer victimization and exposure to community violence, assesses activation of the locus cerulus/autonomic (sympathetic) nervous system and the limbic hypothalamic-pituitary-adrenal (LHPA) axis, and includes youth and parent assessments of emotion regulation skill and coping processes, including coping goals, threat appraisals, coping behaviors, and coping self-efficacy. The study follows a cohort of 200 5th graders, with limited exposure to drugs, and a cohort of 200 8th graders, with substantial exposure to drugs, over a 2-year period through key transitions into middle and high school. Thus, factors associated with both the initiation and exacerbation of drug use will be studied. This study will provide important information on the interaction of biological, environmental, and psychological risk factors for drug use. It has potential to reduce the tremendous societal costs of drug use by identifying behavioral and physiological correlates of inflation and escalation of drug use in adolescence. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DA020086-02
Application #
7502628
Study Section
Special Emphasis Panel (ZRG1-RPHB-H (90))
Program Officer
Deeds, Bethany
Project Start
2007-09-30
Project End
2010-08-31
Budget Start
2008-09-01
Budget End
2010-08-31
Support Year
2
Fiscal Year
2008
Total Cost
$174,582
Indirect Cost
Name
Virginia Commonwealth University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Wright, Anna W; Yendork, Joana Salifu; Kliewer, Wendy (2018) Patterns of Spiritual Connectedness during Adolescence: Links to Coping and Adjustment in Low-Income Urban Youth. J Youth Adolesc 47:2608-2624
Kliewer, Wendy; Yendork, Joana Salifu; Wright, Anna W et al. (2018) Adjustment Profiles of Low-Income Caregivers from the United States and South Africa: Contrasts and Commonalities. J Child Fam Stud 27:522-534
Mize, Jerry L; Kliewer, Wendy (2017) Domain-Specific Daily Hassles, Anxiety, and Delinquent Behaviors among Low-Income, Urban Youth. J Appl Dev Psychol 53:31-39
Kliewer, Wendy; Robins, Jo Lynne W (2017) Cumulative Risk and Physiological Stress Responses in African American Adolescents. Biol Res Nurs 19:428-439
Jäggi, Lena; Kliewer, Wendy (2016) ""Cause That's the Only Skills in School You Need"": A Qualitative Analysis of Revenge Goals in Poor Urban Youth. J Adolesc Res 31:32-58
Kliewer, Wendy; Riley, Tennisha; Zaharakis, Nikola et al. (2016) Emotion dysregulation, anticipatory cortisol, and substance use in urban adolescents. Pers Individ Dif 99:200-205
Kliewer, Wendy; Borre, Alicia; Wright, Anna W et al. (2016) Parental emotional competence and parenting in low-income families with adolescents. J Fam Psychol 30:33-42
Kliewer, Wendy (2016) Victimization and Biological Stress Responses in Urban Adolescents: Emotion Regulation as a Moderator. J Youth Adolesc 45:1812-23
Jäggi, Lena; Drazdowski, Tess K; Kliewer, Wendy (2016) What parents don't know: Disclosure and secrecy in a sample of urban adolescents. J Adolesc 53:64-74
Davis, Tess; Ammons, Chrissy; Dahl, Alexandra et al. (2015) Community Violence Exposure and Callous-Unemotional Traits in Adolescents: Testing Parental Support as a Promotive Versus Protective Factor. Pers Individ Dif 77:7-12

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