This proposal aims to study the cortical representation of the sensory aspect of pain and touch within the traditionally defined secondary somatosensory cortex (SII) located along the Sylvian fissure in non-human primates. By using high resolution fMRI and image-guided electrophysiological recordings in anesthetized squirrel monkeys, we will examine functional roles of the subregions within SII in the processing of basic features of painful and tactile inputs. There are two specific aims.
Aim 1 proposes to determine which subregion(s) within SII cortex is activated during painful and tactile stimulation of individual fingerpads;whether nociceptive and tactile responses colocalize within each activated subregion;whether there is a fine digit topography and stimulus intensity-dependent response for pain and/or touch;and what is the temporal property of the responses. FMRI activation maps to painful heat and vibration will be compared to evaluate the specificity of activation.
Aim 2 proposes to determine the neuronal mechanism underlying the activations revealed by fMRI. FMRI activation maps will be validated and spatially correlated with the maps determined by electrophysiology. By using the fMRI activation maps as a guide, we will place single or multiple electrodes in the activated regions to characterize and record neuronal response properties in response to painful heat, vibration, and rest conditions, and to determine what aspect of neuronal activities (single, multiple neuron, or local field potential) correlates best with the stimulus-response function of the fMRI signal. This study will provide direct evidence relating the existence of nociceptive specific regions within SII cortex and the linkage between neuronal activities and fMRI signal. Ultimately, knowledge gained will have profound impact on our understanding of the cellular mechanism of pain processing and perception. 30

Public Health Relevance

This study centers on understanding which cortical areas encode the location (where), intensity (how strong), and modality of a painful stimulus. If we can understand how these areas are organized and activated during sensory processing, and how they are connected to form a processing network, we will be able to understand the flowchart of information processing in the brain. This knowledge would promote new therapeutic ideas, which will lead to more rational and reliable treatment for pain.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DA024831-02
Application #
7628950
Study Section
Somatosensory and Chemosensory Systems Study Section (SCS)
Program Officer
Aigner, Thomas G
Project Start
2008-07-01
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2011-06-30
Support Year
2
Fiscal Year
2009
Total Cost
$230,250
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Chen, Li Min; Dillenburger, Barbara C; Wang, Feng et al. (2012) Differential fMRI activation to noxious heat and tactile stimuli in parasylvian areas of new world monkeys. Pain 153:158-69
Chen, Li M; Dillenburger, Barbara C; Wang, Feng et al. (2011) High-resolution functional magnetic resonance imaging mapping of noxious heat and tactile activations along the central sulcus in New World monkeys. Pain 152:522-32
Friedman, Robert M; Dillenburger, Barbara C; Wang, Feng et al. (2011) Methods for fine scale functional imaging of tactile motion in human and nonhuman primates. Open Neuroimag J 5:160-71
Lecoeur, Jérémy; Wang, Feng; Chen, Li Min et al. (2011) Automated longitudinal registration of high resolution structural MRI brain sub-volumes in non-human primates. J Neurosci Methods 202:99-108
Zhang, N; Wang, F; Turner, G H et al. (2010) Intra- and inter-subject variability of high field fMRI digit maps in somatosensory area 3b of new world monkeys. Neuroscience 165:252-64
Braskie, Meredith N; Klunder, Andrea D; Hayashi, Kiralee M et al. (2010) Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease. Neurobiol Aging 31:1669-78
Braskie, Meredith N; Small, Gary W; Bookheimer, Susan Y (2010) Vascular health risks and fMRI activation during a memory task in older adults. Neurobiol Aging 31:1532-42