Evaluating the combination of the Adolescent Community Reinforcement Approach and medication- assisted treatment in young adults with severe opioid use disorder Project Summary The proposed study will assess whether adding a behavioral intervention, known as the Adolescent Community Reinforcement Approach (A-CRA), to the treatment of individuals receiving buprenorphine/naloxone can improve treatment success and retention rates in young adults with severe opioid use disorder. Forty young adults between ages 18 and 25 who would typically qualify for treatment with buprenorphine/naloxone at an academic outpatient site, will be randomized to receive 12 weeks of A-CRA treatment, or limited counseling. We plan to: (1) collect pre- and post-treatment assessments of opioid use and overall impact of addiction using the Global Appraisal of Individual Needs (GAIN) measures; (2) collect weekly urine drug screens; (3) measure treatment retention in all participants at weeks 2, 12, and 24; (4) compare retention rates and treatment success measures between the experimental (combined treatment) and control (limited counseling) groups. The information generated from this study will provide evidence to support a tailored treatment approach for this high-risk demographic of individuals with opioid use disorder.

Public Health Relevance

The aim of this proposal is to assess whether adding a behavioral intervention, known as the Adolescent Community Reinforcement Approach, to the standard buprenorphine maintenance treatment can improve opioid use disorder treatment outcomes. This preliminary work may support the use of A-CRA and medication-assisted treatment as the standard of care in opioid use disorders for young adults.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21DA046738-01
Application #
9584676
Study Section
Nursing and Related Clinical Sciences Study Section (NRCS)
Program Officer
Mulford, Carrie Fried
Project Start
2018-09-30
Project End
2020-08-31
Budget Start
2018-09-30
Budget End
2019-08-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Emory University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322