An exploratory research is proposed to develop micro-sensors that can be used as implant microphones to sense the sound vibration of the middle ear structure and to convert it into high quality electrical signals for the input of implant cochlear or middle-ear hearing systems. The proposed project will bring together the medical and engineering investigators to integrate the expertise in hearing physiology, sensor design, micro-machining technology, and micro-electronics with the aims: (1) to study novel sensor mechanisms that can function in the middle ear chamber without packaging and presents minimum loading [less than 10 mg] to the ossicles; (2) to develop design and fabrication processes of the implantable sensor that can detect the sound vibration of ossicles without alter the structure and does not require critical positioning of the sensor in the middle ear chamber; (3) to design and fabricate the micropowered electronics circuit to amplify the sound signal to a level that can be coupled to the input of the existing cochlear implant system or can be connected to an implant middle ear actuator to provide adequate hearing aid function; and (4) to evaluate the prototype sensor and the bio-electronic microphone in the laboratory and in the temporal bone expedients to assess the feasibility of pursuing the future development of totally implantable cochlear system and middle ear hearing device. When the result of this exploratory study justifies, a continuation proposal will be submitted for further study to develop and fabricate the clinical version of micro-sensors and to evaluate them in animals as well as selected clinical cases for the development of totally implantable cochlear systems or middle ear hearing devices.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DC006850-02
Application #
6831705
Study Section
Special Emphasis Panel (ZRG1-SSS-A (50))
Program Officer
Miller, Roger
Project Start
2003-12-05
Project End
2006-11-30
Budget Start
2004-12-01
Budget End
2006-11-30
Support Year
2
Fiscal Year
2005
Total Cost
$229,500
Indirect Cost
Name
Case Western Reserve University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Young, Darrin J; Zurcher, Mark A; Semaan, Maroun et al. (2012) MEMS capacitive accelerometer-based middle ear microphone. IEEE Trans Biomed Eng 59:3283-92
Young, Darrin J; Zurcher, Mark A; Trang, Tung et al. (2010) Characterization of ossicular chain vibration at the umbo: implications for a middle ear microelectromechanical system design. Ear Nose Throat J 89:21-6
Huang, Ping; Guo, Jun; Megerian, Cliff A et al. (2007) A laboratory study on a capacitive displacement sensor as an implant microphone in totally implant cochlear hearing aid systems. Conf Proc IEEE Eng Med Biol Soc 2007:5692-5
Zurcher, Mark A; Young, Darrin J; Semaan, Maroun et al. (2006) Effect of incus removal on middle ear acoustic sensor for a fully implantable cochlear prosthesis. Conf Proc IEEE Eng Med Biol Soc 1:539-42