Although many treatment paradigms exist for aphasia rehabilitation with behaviorally successful outcomes, there is still much debate regarding the ?best? pattern of neural reorganization during recovery. This lack of consensus may be due, in part, to incomplete exploration of the link between neural reorganization and behavior. The proposed project will apply graph theoretical measures to both task-based and resting-state fMRI (rs-fMRI) data to examine changes in functional connectivity related to treatment outcomes in persons with aphasia. Graph theory and rs-fMRI are currently underutilized in clinical aphasiology. Graph theory is gaining popularity in other areas of cognitive science as a meaningful technique for the characterization of brain network dynamics. Resting-state fMRI has been gaining popularity in other areas of clinical research as an easily acquired and informative measure of general cognitive functioning. Twenty participants with aphasia (PWA) will be scanned using fMRI at four time points. Between scan 1 and scan 2, no therapy will be provided, establishing a baseline control for each PWA. Between scan 2 and scan 3, ten weeks of word finding therapy will be provided. Between scan 3 and scan 4, no therapy will be provided, allowing for measurement of maintenance effects. The treatment used is abstract word retrieval training. This treatment was chosen because it has been shown to be not only successful at improving abstract word retrieval, but also improving retrieval of related concrete words that are not trained (i.e., generalization) (Kiran, Sandberg, & Abbott, 2009; Sandberg & Kiran, 2014). This makes the treatment more effective and a good candidate for promoting positive neural changes. Furthermore, abstract and concrete words have been shown to have differing neural activation patterns. This allows for the systematic examination of direct training and generalization effects of treatment on brain reorganization. For the graph theory analysis, regions of interest (ROIs) will be defined using a data-driven spatially-constrained approach developed by Drs. Hillary and Molenaar. Once correlations matrices are defined for each time point, graph theoretical measures will be calculated and compared at each time point to systematically examine changes in functional connectivity related to therapy outcomes. The methodological approach in this proposal is innovative in the use of two baseline scans before treatment and two maintenance scans after treatment and the application of graph theory and rs-fMRI to examine treatment-related brain reorganization in aphasia. The successful completion of this project is expected to help inform current theories of optimal reorganization patterns after stroke and provide groundwork for establishing informative and appropriate methods for measuring brain reorganization in aphasia.

Public Health Relevance

The proposed project is relevant to public health because it is designed to address the important issue of rehabilitation of aphasia after stroke. Linking behavioral recovery of language function with neurophysiological changes in the brains of persons with chronic aphasia is important for understanding the role that language therapy plays in the positive reorganization of function. A more complete understanding of this relationship will aid in the development of better therapy that facilitates more optimal rehabilitative outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21DC016708-01A1
Application #
9591636
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Cooper, Judith
Project Start
2018-06-01
Project End
2021-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Psychology
Type
Sch Allied Health Professions
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802