Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DE015075-02
Application #
6683643
Study Section
Special Emphasis Panel (ZDE1-YL (70))
Program Officer
Nokta, Mostafa A
Project Start
2002-12-01
Project End
2004-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$133,886
Indirect Cost
Name
University of Otago
Department
Type
DUNS #
590135182
City
Dunedin
State
Country
New Zealand
Zip Code
9054
Keniya, Mikhail V; Cannon, Richard D; Nguy?n, ÂnBình et al. (2013) Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae. FEMS Yeast Res 13:302-11
Niimi, Kyoko; Harding, David R K; Holmes, Ann R et al. (2012) Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a D-octapeptide derivative inhibitor. Mol Microbiol 85:747-67
Lamping, Erwin; Cannon, Richard D (2010) Use of a yeast-based membrane protein expression technology to overexpress drug resistance efflux pumps. Methods Mol Biol 666:219-50
Lamping, Erwin; Ranchod, Amrita; Nakamura, Kenjirou et al. (2009) Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrob Agents Chemother 53:354-69
Holmes, Ann R; Lin, Ya-Hsun; Niimi, Kyoko et al. (2008) ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates. Antimicrob Agents Chemother 52:3851-62
Lamping, Erwin; Monk, Brian C; Niimi, Kyoko et al. (2007) Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae. Eukaryot Cell 6:1150-65
Holmes, Ann R; Tsao, Sarah; Lamping, Erwin et al. (2006) Amino acid residues affecting drug pump function in Candida albicans--C. albicans drug pump function. Nippon Ishinkin Gakkai Zasshi 47:275-81
Niimi, K; Maki, K; Ikeda, F et al. (2006) Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility. Antimicrob Agents Chemother 50:1148-55
Holmes, Ann R; Tsao, Sarah; Ong, Soo-Wee et al. (2006) Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2. Mol Microbiol 62:170-86
Monk, Brian C; Niimi, Kyoko; Lin, Susan et al. (2005) Surface-active fungicidal D-peptide inhibitors of the plasma membrane proton pump that block azole resistance. Antimicrob Agents Chemother 49:57-70

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