The overall goal of this project is to develop a robust magnetic resonance spectroscopy (MRS) methodology to reliably measure cerebral GABA concentration in both the clinical and research settings. At present GABA spectroscopy sequences are limited by large voxel size and long imaging times. The present proposal seeks to develop a spectroscopy methodology, which can be used to look at a definite functionally relevant portion of brain parenchyma in a time short enough for the patient to remain consistently still; it also needs to remain sensitive to changes in GABA produced by the underlying pathology. The project also aims to demonstrate that the developed methodology is sensitive enough to detect a 20% change in GABA concentration with a 95% confidence interval. Upon completion, this methodology should be useful in studying GABA level at specific cortical regions in a number of neuropsychiatric patient populations (e.g. depression, hepatic encephalopathy, focal dystonia, cocaine abuse patients, juvenile myoclonic epilepsy, and panic disorder) marked by reduction in GABA concentration. This study aims to develop a MRS methodology based on MEGA-PRESS sequence for GABA editing to reliably measure GABA for the first time in the motor cortex of a normal control population. First year of this two year long study will be dedicated in developing the methodology by scanning phantoms and normal controls in a 3 Tesla Siemens Trio scanner and in the second year more scans will be performed to demonstrate the sensitivity of the methodology. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21EB005302-02
Application #
7268093
Study Section
Special Emphasis Panel (ZRG1-BDCN-K (10))
Program Officer
Mclaughlin, Alan Charles
Project Start
2006-07-01
Project End
2009-06-30
Budget Start
2007-07-01
Budget End
2009-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$179,852
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Bhattacharyya, Pallab K; Phillips, Micheal D; Stone, Lael A et al. (2017) Activation volume vs BOLD signal change as measures of fMRI activation - Its impact on GABA - fMRI activation correlation. Magn Reson Imaging 42:123-129
Bhattacharyya, P K; Phillips, M D; Stone, L A et al. (2013) Sensorimotor cortex gamma-aminobutyric acid concentration correlates with impaired performance in patients with MS. AJNR Am J Neuroradiol 34:1733-9
Bhattacharyya, Pallab K; Phillips, Micheal D; Stone, Lael A et al. (2011) In vivo magnetic resonance spectroscopy measurement of gray-matter and white-matter gamma-aminobutyric acid concentration in sensorimotor cortex using a motion-controlled MEGA point-resolved spectroscopy sequence. Magn Reson Imaging 29:374-9
Fox, Robert J; Beall, Erik; Bhattacharyya, Pallab et al. (2011) Advanced MRI in multiple sclerosis: current status and future challenges. Neurol Clin 29:357-80
Bhattacharyya, P K; Lowe, M J; Phillips, M D (2007) Spectral quality control in motion-corrupted single-voxel J-difference editing scans: an interleaved navigator approach. Magn Reson Med 58:808-12