Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Exploratory/Developmental Grants (R21)
Project #
3R21ES013022-01S1
Application #
6935718
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Kirshner, Annette G
Project Start
2004-05-01
Project End
2007-03-31
Budget Start
2004-08-01
Budget End
2005-03-31
Support Year
1
Fiscal Year
2004
Total Cost
$25,774
Indirect Cost
Name
University of Rhode Island
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
796475382
City
Kingston
State
RI
Country
United States
Zip Code
02881
Subaiea, Gehad M; Ahmed, Aseef H; Adwan, Lina I et al. (2015) Reduction of amyloid-? deposition and attenuation of memory deficits by tolfenamic acid. J Alzheimers Dis 43:425-33
Ahmed, Aseef H; Subaiea, Gehad M; Eid, Aseel et al. (2014) Pomegranate extract modulates processing of amyloid-? precursor protein in an aged Alzheimer's disease animal model. Curr Alzheimer Res 11:834-43
Subaiea, Gehad M; Adwan, Lina I; Ahmed, Aseef H et al. (2013) Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice. Neurobiol Aging 34:2421-30
Dosunmu, Remi; Alashwal, Hany; Zawia, Nasser H (2012) Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging. Mech Ageing Dev 133:435-43
Alashwal, Hany; Dosunmu, Remi; Zawia, Nasser H (2012) Integration of genome-wide expression and methylation data: relevance to aging and Alzheimer's disease. Neurotoxicology 33:1450-3
Subaiea, Gehad M; Alansi, Bothaina H; Serra, David A et al. (2011) The ability of tolfenamic acid to penetrate the brain: a model for testing the brain disposition of candidate Alzheimer's drugs using multiple platforms. Curr Alzheimer Res 8:860-7
Adwan, L I; Basha, R; Abdelrahim, M et al. (2011) Tolfenamic acid interrupts the de novo synthesis of the ?-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway. Curr Alzheimer Res 8:385-92
Zawia, Nasser H; Lahiri, Debomoy K; Cardozo-Pelaez, Fernando (2009) Epigenetics, oxidative stress, and Alzheimer disease. Free Radic Biol Med 46:1241-9
Dosunmu, Remi; Wu, Jinfang; Adwan, Lina et al. (2009) Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice. J Alzheimers Dis 18:211-30
Brock, Brian; Basha, Riyaz; DiPalma, Katie et al. (2008) Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis. J Alzheimers Dis 13:71-80

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