Abstract

The pioneering of laser surgery and ocular coherence tomography by eye researchers has had a tremendous global health impact upon the current ability to diagnose, understand, treat, and monitor multiple eye diseases. The potential of combining these two powerful modalities into a miniature intraocular probe to monitor and guide real-time laser surgery is untapped. Advances in surgical outcomes will occur with new devices to increase the technical precision of surgeons. This project proposes that a system with a miniature probe can be developed that monitors real-time incision of a tissue layer to protect the underlying tissues from injury. To achieve precise image-guided incisions, a customized real-time spectral domain optical coherence tomography (SDOCT) imaging system will be combined with a novel table-top 6.1 Aim I. An IR laser waveguide probe and a novel SDOCT imaging probe will be developed and then combined into an ergonomic 20-gauge probe for intraocular surgery.
Aim II. Optimize and demonstrate feasibility of the SDOCT system to evaluate real-time laser incising of artificially detached retinas (retinectomy procedure) delivered through the 20-gauge probe.

Public Health Relevance

The goal is to achieve safe image-guided incisions by combining light-imaging technology with an incising laser in a miniature probe. The imaging will be exploited to detect incision of a tissue layer as it occurs to protect the underlying structures from injury. This concept will be explored in a retinal intraocular procedure, but has profound relevance for multiple surgical areas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21EY019752-02
Application #
7931947
Study Section
Special Emphasis Panel (ZRG1-SBIB-J (90))
Program Officer
Mariani, Andrew P
Project Start
2009-09-01
Project End
2012-02-29
Budget Start
2010-09-01
Budget End
2012-02-29
Support Year
2
Fiscal Year
2010
Total Cost
$193,963
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Yu, Haoran; Shen, Jin-Hui; Shah, Rohan J et al. (2015) Evaluation of microsurgical tasks with OCT-guided and/or robot-assisted ophthalmic forceps. Biomed Opt Express 6:457-72
Joos, Karen M; Shen, Jin-Hui (2014) Preliminary Design and Evaluation of a B-Scan OCT-Guided Needle. Photonics 1:260-266
Li, Zhuoyan; Shen, Jin H; Kozub, John A et al. (2014) Miniature forward-imaging B-scan optical coherence tomography probe to guide real-time laser ablation. Lasers Surg Med 46:193-202