Dynamic mapping of complex brain circuits by monitoring and modulating brain activity at large scale will enhance our understanding of brain functions, such as sensation, thought, emotion, and action, and also has the potential to enhance our perceptual, motor, and cognitive capabilities, as well as to restore sensory and motor functions lost through injuries or diseases. This project aims to develop a bidirectional, hybrid electrical- acoustic, minimally invasive, wireless, and implantable neural-interface platform for electrophysiology recording and ultrasonic stimulation of neural activities with high spatiotemporal resolution at a large scale.