The goal of the proposed research is to develop one or more C. elegans genetic models for intestine and kidney transporter defects. We have identified eight nematode homologues of transporters directly implicated in digestive and renal disease or otherwise thought to be important in the functions of these organs. In this project, we propose to characterize the expression patterns of the nematode proteins and determine the properties of animals defective in their functions. Based on this information, stable loss of function mutations will be sought for those genes judged to be the most promising candidates for transporter disease models.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21GM065810-02
Application #
6526907
Study Section
Special Emphasis Panel (ZDK1-GRB-3 (O1))
Program Officer
Chin, Jean
Project Start
2001-09-24
Project End
2004-08-31
Budget Start
2002-09-01
Budget End
2004-08-31
Support Year
2
Fiscal Year
2002
Total Cost
$152,000
Indirect Cost
Name
University of Washington
Department
Genetics
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195