Abstract

The grant proposes to study immune reconstitution in HIV infected infants treated with HAART. The primary hypothesis tested is that children treated at an early age with maximum suppression of viral replication with have a greater potential for normalization of immune function than older patients. In addition, the authors will attempt to identify and quantify the cellular reservoirs for infectious and latent viral infection in HIV infected infants post-HAART and we will study HIV co-receptor use and tropism of latent virus which is found to be present post-HAART to infect thymocytes and macrophages will also be studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21HD037593-02
Application #
2889587
Study Section
Special Emphasis Panel (ZRG5-AARR-2 (03))
Program Officer
Lock, Allan
Project Start
1998-09-30
Project End
2001-08-31
Budget Start
1999-09-01
Budget End
2001-08-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Pediatrics
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Ching, Natascha; Yang, Otto O; Deville, Jaime G et al. (2007) Pediatric HIV-1-specific cytotoxic T-lymphocyte responses suggesting ongoing viral replication despite combination antiretroviral therapy. Pediatr Res 61:692-7
Pedroza-Martins, Livia; Boscardin, W John; Anisman-Posner, Deborah J et al. (2002) Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants. J Virol 76:6929-43