Profoundly impaired mobility is a major consequence of stroke. As a result, a large number of more than 700,000 people in America sustaining a stroke each year have limitations in motor ability and compromised quality of life. It is a fact that individuals with hemiparesis frequently bear the majority of their body weight through their uninvolved lower extremity. Asymmetry of stance and weight bearing has been recognized as a predictor of the ability to ambulate. Therefore, achieving symmetry of stance and gait is considered an important goal of rehabilitation. However, therapeutic interventions designed to enhance motor function and promote independence following stroke are quite limited. We have developed a new technique that preliminary studies suggest can substantially improve gait pattern, reduce the incapacitating motor deficit of stroke patients, and increase their independence. The technique, termed Compelled Body-Weight Shift (CBWS) therapy, involves lift of the nonaffected lower extremity through the use of a shoe insert over a period of several weeks. During this time, more symmetrical weight bearing is facilitated while patients participate in physical therapy as well as regular daily activities. The proposed research builds on findings from a pilot study that demonstrated significant gains in individuals with chronic unilateral stroke following CBWS therapy. The experimental design randomly assigns patients who are more than 1 year post-stroke to two groups. The experimental group will receive CBWS therapy combined with conventional physical therapy for a period of six weeks, the control group will only receive conventional physical therapy. Immediate and longer-term (four months out) results from both groups will be compared.
The specific aims are: (1) to test the efficacy of CBWS therapy compared to conventional therapy alone in improving gait and symmetry of weight bearing; (2) to evaluate whether the improvement is sustained post-CBWS therapy. This research is of paramount significance because, if successful, the outcomes from the study could be used to refocus conventional rehabilitation strategies aimed at helping chronic stroke patients to achieve maximal independence in mobility and activities of daily living. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21HD050457-01A1
Application #
7101579
Study Section
Motor Function, Speech and Rehabilitation Study Section (MFSR)
Program Officer
Shinowara, Nancy
Project Start
2006-05-20
Project End
2008-04-30
Budget Start
2006-05-20
Budget End
2007-04-30
Support Year
1
Fiscal Year
2006
Total Cost
$159,976
Indirect Cost
Name
University of Illinois at Chicago
Department
Other Health Professions
Type
Schools of Allied Health Profes
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Aruin, Alexander S; Rao, Noel; Sharma, Asha et al. (2012) Compelled body weight shift approach in rehabilitation of individuals with chronic stroke. Top Stroke Rehabil 19:556-63
Mohapatra, Sambit; Eviota, Aileen C; Ringquist, Keir L et al. (2012) Compelled Body Weight Shift Technique to Facilitate Rehabilitation of Individuals with Acute Stroke. ISRN Rehabil 2012:
Santos, Marcio J; Kanekar, Neeta; Aruin, Alexander S (2010) The role of anticipatory postural adjustments in compensatory control of posture: 2. Biomechanical analysis. J Electromyogr Kinesiol 20:398-405
Rao, Noel; Nashner, Lew; Aruin, Alexander S (2010) Perceived body position in standing individuals with recent stroke. Clin Neurophysiol 121:1934-8
Santos, Marcio J; Kanekar, Neeta; Aruin, Alexander S (2010) The role of anticipatory postural adjustments in compensatory control of posture: 1. Electromyographic analysis. J Electromyogr Kinesiol 20:388-97
Santos, Marcio J; Aruin, Alexander S (2009) Effects of lateral perturbations and changing stance conditions on anticipatory postural adjustment. J Electromyogr Kinesiol 19:532-41
Iyengar, Veena; Santos, Marcio J; Aruin, Alexander S (2009) Role of movement velocity on the magnitude of grip force while lifting an object with touch from the contralateral finger. Motor Control 13:130-41
Li, Xiaoyan; Aruin, Alexander S (2009) The effect of short-term changes in body mass distribution on feed-forward postural control. J Electromyogr Kinesiol 19:931-41
Rao, Noel; Chaudhuri, Gouri; Hasso, Daniel et al. (2008) Gait assessment during the initial fitting of an ankle foot orthosis in individuals with stroke. Disabil Rehabil Assist Technol 3:201-7
Kanekar, Neeta; Santos, Marcio J; Aruin, Alexander S (2008) Anticipatory postural control following fatigue of postural and focal muscles. Clin Neurophysiol 119:2304-13

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