About 10-15% of couples suffer from infertility and its prevalence is increasing in the United States. Use of infertility services constitutes a major economic burden, and success rates of treatment are relatively low. We propose to conduct an internet-based feasibility study of risk factors for delayed time-to-pregnancy (TTP), a sensitive indicator of a couple's fertility. With targeted internet advertisements on FACEBOOK (popular social- networking website) and other social- and health-related websites, we will recruit a cohort of 2,500 female residents of Massachusetts aged 21-44 years who are planning a pregnancy. To increase minority enrollment, we will oversample African American (20%) and Hispanic (15%) women. After a short run-in period to verify a participant's identity and willingness to participate in a year-long study, participants will be followed using web-based questionnaires every 8 weeks for 12 months or until clinically-recognized pregnancy occurs, whichever comes first. The male partners of female participants will be asked to complete a web- based baseline questionnaire on lifestyle and medical history. Half of enrolled women will be randomized at baseline to receive free access to web-based menstrual charting software (FertilityFriend.com), available to them via both computer and smartphone. The primary aim of the study will be to assess the feasibility, validity, and efficiency of using the internet for recruitment, follow-up, and data collection. Secondarily, it will evaluate several potential risk factors for delayed TTP, including caffeine, anthropometric factors, physical activity, and antidepressant use. Thirdly, it will assess whether use of the web-based menstrual charting software increases cohort retention and shortens TTP. In a subset of women who conceive and deliver births during the first 12 months of the study, we will link questionnaire data with birth registry data from the Massachusetts Department of Public Health Registry of Vital Records. Registry data will be used to validate self-reported TTP and other questionnaire data (e.g., prepregnancy body mass index). We have given priority to common risk factors for which existing studies of their relation to TTP are inconclusive. The proposed prospective design is novel because most studies of fecundability have evaluated the TTP retrospectively among women who become pregnant, a method prone to selection and recall biases. Moreover, no previous TTP study has evaluated the impact of incorporating web-based menstrual charting software into its protocol. The internet will allow us to identify women planning a pregnancy, a challenging population to target using traditional epidemiologic methods. Recently, our research team demonstrated that internet-based methods are an efficient and cost-effective means of recruitment and follow-up in a prospective cohort study of TTP in Denmark. However, the feasibility of these methods remains to be tested in the United States. Such a design could have far-ranging implications for the practice of epidemiology.

Public Health Relevance

Ten to 15% of all couples have difficulty becoming pregnant, and the prevalence of infertility is increasing in the United States. The proposed study will test the feasibility of using the internet to recruit and follow participants in a prospective cohort stdy of time-to-pregnancy. It will also identify modifiable risk factors for subfertility among the wome who conceive, yielding important public health information about a condition that affects large numbers of reproductive-aged women.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Exploratory/Developmental Grants (R21)
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Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section (IRAP)
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Eisenberg, Esther
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Boston University
Public Health & Prev Medicine
Schools of Medicine
United States
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Nillni, Yael I; Wesselink, Amelia K; Hatch, Elizabeth E et al. (2018) Mental health, psychotropic medication use, and menstrual cycle characteristics. Clin Epidemiol 10:1073-1082
Hatch, Elizabeth E; Wesselink, Amelia K; Hahn, Kristen A et al. (2018) Intake of Sugar-sweetened Beverages and Fecundability in a North American Preconception Cohort. Epidemiology 29:369-378
Wise, Lauren Anne; Rothman, Kenneth Jay; Wesselink, Amelia Kent et al. (2018) Male sleep duration and fecundability in a North American preconception cohort study. Fertil Steril 109:453-459
Wise, Lauren A; Wesselink, Amelia K; Tucker, Katherine L et al. (2018) Dietary Fat Intake and Fecundability in 2 Preconception Cohort Studies. Am J Epidemiol 187:60-74
McInerney, K A; Hahn, K A; Hatch, E E et al. (2018) Lubricant use during intercourse and time to pregnancy: a prospective cohort study. BJOG 125:1541-1548
Wise, Lauren A; Wesselink, Amelia K; Mikkelsen, Ellen M et al. (2017) Dairy intake and fecundability in 2 preconception cohort studies. Am J Clin Nutr 105:100-110
McInerney, Kathryn A; Hatch, Elizabeth E; Wesselink, Amelia K et al. (2017) The Effect of Vaccination Against Human Papillomavirus on Fecundability. Paediatr Perinat Epidemiol 31:531-536
Wesselink, Amelia K; Rothman, Kenneth J; Hatch, Elizabeth E et al. (2017) Age and fecundability in a North American preconception cohort study. Am J Obstet Gynecol 217:667.e1-667.e8
McInerney, Kathryn A; Hatch, Elizabeth E; Wesselink, Amelia K et al. (2017) Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study. Hum Reprod 32:103-111
Wesselink, Amelia K; Wise, Lauren A; Hatch, Elizabeth E et al. (2016) Menstrual cycle characteristics and fecundability in a North American preconception cohort. Ann Epidemiol 26:482-487.e1

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