Bulbar dysfunction in the form of progressive speech, swallow and respiratory impairment are highly prevalent in Amyotrophic Lateral Sclerosis (ALS) and together account for 95% of disease mortality. Although progressive muscle weakness is the primary sign of ALS, the effects of exercise and strength training in this patient population i controversial. While exercise in persons with ALS has historically been discouraged due to fear that muscle overburden may execrate physical decline, recent animal and human data suggest that moderate intensity exercise applied early in the disease may serve a neuroprotective role in ALS. Indeed, exciting preliminary data from our laboratory indicate that a regimen of expiratory muscle strength training (EMST) in persons with mild-moderate ALS has a positive effect on expiratory force generating abilities, airway protection and cough during swallowing, swallow kinematics, self-reported swallow severity and swallow- related quality of life. The central goal o this proposal is to investigate the effects of an eight-week regimen of EMST on bulbar function in persons with mild to moderate ALS using a blinded, sham-controlled, randomized clinical trial. The central hypothesis of this proposal is that eight-weeks of daily moderate intensity resistance EMST exercise will actively engage the expiratory and submental musculature, deter disuse atrophy and prolong function of airway protection, swallowing and functional oral intake in persons with ALS. The proposed study is designed to specifically determine the effect of EMST on: 1) expiratory force generating ability (maximum expiratory pressure);2) swallow physiology and airway safety during swallow;3) cough function;4) functional oral intake, swallow-related quality of life and self-reported swallow severity;5) and subsequent disease progression in persons with mild to moderate ALS. The results will provide valuable insight into the potential role of muscle strength training for improving bulbar function in persons with ALS and will help guide the future direction of research and treatment for this devastating disorder.

Public Health Relevance

The results will provide valuable insight into the potential role of muscle strength training for improving bulbar function in persons with Amyotrophic Lateral Sclerosis (ALS) and will help guide the future direction of research and treatment for this devastating disorder. Better treatment strategies for swallowing dysfunction in ALS will lead to improvements in quality of life and reductions in individual health care costs, total economic burden, caregiver burden, aspiration pneumonia and ultimately mortality in this disease population.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21HD075327-01A1
Application #
8582789
Study Section
Motor Function, Speech and Rehabilitation Study Section (MFSR)
Program Officer
Michel, Mary E
Project Start
2013-07-15
Project End
2015-06-30
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$214,548
Indirect Cost
$64,548
Name
University of South Florida
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33612
Tabor, Lauren; Gaziano, Joy; Watts, Stephanie et al. (2016) Defining Swallowing-Related Quality of Life Profiles in Individuals with Amyotrophic Lateral Sclerosis. Dysphagia 31:376-82
Plowman, Emily K; Watts, Stephanie A; Robison, Raele et al. (2016) Voluntary Cough Airflow Differentiates Safe Versus Unsafe Swallowing in Amyotrophic Lateral Sclerosis. Dysphagia 31:383-90
Watts, Stephanie A; Tabor, Lauren; Plowman, Emily K (2016) To Cough or Not to Cough? Examining the Potential Utility of Cough Testing in the Clinical Evaluation of Swallowing. Curr Phys Med Rehabil Rep 4:262-276
Tabor, Lauren C; Rosado, Karen M; Robison, Raele et al. (2016) Respiratory training in an individual with amyotrophic lateral sclerosis. Ann Clin Transl Neurol 3:819-823
Plowman, E K; Tabor, L C; Robison, R et al. (2016) Discriminant ability of the Eating Assessment Tool-10 to detect aspiration in individuals with amyotrophic lateral sclerosis. Neurogastroenterol Motil 28:85-90