Statistical models for social networks have a long history in related public-health and the social and behavioral sciences. They can be used to provide precise stochastic representations of complex social structure, to compare theory to data and to simulate virtual networked populations that retain the essential properties of a theory or of data. This project will address fundamental issues in the statistical modeling of social networks and expands the existing capabilities. These are directly applicable to the epidemiological aspects of HIV/AIDS and STI both in the U.S. and internationally. Exponential-family random graph models are capable of representing the complex dependencies in social phenomena, and have been well studied in SNA. However, they do not represent the social endogeneity of nodal characteristics but only that of the relations. This project will address this deficiency by jointly stochastically modeling both the relational and individual variables via a novel class of exponential-family random network models. The majority of network data collection relies on sampling of the social network or is subject to missing data issues when a census is attempted. This project will develop new forms of network link- tracing designs that more efficiently collects information from the network while preserving the privacy of the networked population. Valid statistical inference from link-traced data is difficult because of th strong and often unknown dependencies in it. This project will develop a new framework for likelihood-based inference for social network models based on link-traced data when the covariates and outcome variables measured on the nodes are social endogenous. Many questions in health-related SNA are multivariate and can be stated as hypotheses about regressions of individual outcome variables on other covariates and their relational information. This project will extend network regression models to the more realistic situation where the outcomes, covariates and social relations are socially endogenous. The conceptual and methodological innovations will be applied to inferring HIV / STI prevalence among the IDU population in Los Angeles County and to HIV / STI among MSM in EU counties via the SIALON II project. The IDU data arise from an innovative link-tracing design to sample this hard-to- reach population. The social network structure of IDU will be inferred, and network regression will be used to analyze their HIV / STI prevalence. Privatized network sampling will be used in the MSN study.

Public Health Relevance

Social interactions and processes are important determinants of human health, and especially the epidemiological aspects of HIV/AIDS and STI. This project addresses fundamental issues in the statistical modeling of social networks and expands the existing capabilities. These include better models for social processes, better ways to collect data, and better ways to identify factors important for health outcomes.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Exploratory/Developmental Grants (R21)
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AIDS Clinical Studies and Epidemiology Study Section (ACE)
Program Officer
Newcomer, Susan
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University of California Los Angeles
Biostatistics & Other Math Sci
Schools of Arts and Sciences
Los Angeles
United States
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Hicks, Andrew L; Handcock, Mark S; Sastry, Narayan et al. (2018) Sequential Neighborhood Effects: The Effect of Long-Term Exposure to Concentrated Disadvantage on Children's Reading and Math Test Scores. Demography 55:1-31
Handcock, Mark S (2018) Comment. J Am Stat Assoc 112:1537-1539
Spiller, Michael W; Gile, Krista J; Handcock, Mark S et al. (2017) Evaluating Variance Estimators for Respondent-Driven Sampling. J Surv Stat Methodol 2017:
Johnston, Lisa G; McLaughlin, Katherine R; El Rhilani, Houssine et al. (2015) Estimating the Size of Hidden Populations Using Respondent-driven Sampling Data: Case Examples from Morocco. Epidemiology 26:846-52
Gile, Krista J; Handcock, Mark S (2015) Network Model-Assisted Inference from Respondent-Driven Sampling Data. J R Stat Soc Ser A Stat Soc 178:619-639
Wesson, Paul; Handcock, Mark S; McFarland, Willi et al. (2015) If You Are Not Counted, You Don't Count: Estimating the Number of African-American Men Who Have Sex with Men in San Francisco Using a Novel Bayesian Approach. J Urban Health 92:1052-64
Admiraal, Ryan; Handcock, Mark S (2015) A log-linear modelling approach to assessing the consistency of ego reports of dyadic outcomes with applications to fertility and sexual partnerships. J R Stat Soc Ser A Stat Soc 178:363-382
Handcock, Mark S; Gile, Krista J; Mar, Corinne M (2015) Estimating the size of populations at high risk for HIV using respondent-driven sampling data. Biometrics 71:258-266
Schweinberger, Michael; Handcock, Mark S (2015) Local dependence in random graph models: characterization, properties and statistical inference. J Am Stat Assoc 77:647-676
Handcock, Mark S; Gile, Krista J; Mar, Corinne M (2014) Estimating hidden population size using Respondent-Driven Sampling data. Electron J Stat 8:1491-1521

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