Adverse childhood experiences (ACEs) involving threat and deprivation early in development have pervasive and long-lasting negative effects on physical and mental health, including health risk behaviors, increased levels of biomarkers for disease, depression, posttraumatic stress disorder, and disruptive behavior disorders. The long-term harmful effects of early ACEs are mediated and moderated by biological, psychological, behavioral, and environmental processes later in development. Specifically, stress sensitivity models of risk have shown that the effects of early ACEs are exacerbated by exposure to stressful events and chronic adversity, including additional exposure to ACEs, later in development, with early adolescence representing a particularly vulnerable developmental period. Continued development of interventions to reduce physical and mental health problems associated with early ACEs and later exposure to stress depends on improved understanding of mechanisms of risk and resilience associated with exposure to stress during adolescence. Recent research suggests that important target mechanisms for interventions involves processes of emotion regulation (ER) and physiological reactivity (PR) in response to stress in adolescents and their caregivers, as deficits and disruptions in these processes increase the risk for physical and mental health problems associated with stress during adolescence (Compas et al., 2017). The proposed project will test a comprehensive multi-method protocol that includes a novel laboratory paradigm using video-mediated recall (VMR) and state-of-the-art measures to examine processes of emotion regulation in response to current stress, along with closely related processes of physiological reactivity, in adolescents who have been exposed to varying levels of ACEs early in development and their current caregivers. We will test the convergence of multiple measures of ER in adolescents and their caregivers, provide an initial test of latent indicators of adolescent and caregiver ER as predictors of symptoms of adolescent physical health problems and psychopathology, and set the stage for larger longitudinal and intervention studies with adolescents who have experienced early ACEs.

Public Health Relevance

This research will examine processes of emotion regulation and physiological reactivity in adolescents who have experienced varying levels of exposure to Adverse Childhood Experiences (ACEs) and their caregivers. The project will test a comprehensive multi-method protocol that includes a novel laboratory paradigm using video-mediated recall and state-of-the-art measures to examine processes of emotion regulation in response to current stress, along with closely related processes of physiological and emotional reactivity, in adolescents who have been exposed to varying levels of ACEs early in development and their caregivers. We will test the convergence of multiple measures of ER in adolescents and their caregivers, provide an initial test of latent indicators of adolescent and caregiver ER as predictors of symptoms of adolescent physical health problems and psychopathology, and set the stage for larger longitudinal and intervention studies with adolescents who have experienced early ACEs.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21HD098454-01A1
Application #
9824667
Study Section
Psychosocial Development, Risk and Prevention Study Section (PDRP)
Program Officer
Esposito, Layla E
Project Start
2019-08-05
Project End
2021-07-31
Budget Start
2019-08-05
Budget End
2020-07-31
Support Year
1
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Psychology
Type
Schools of Education
DUNS #
965717143
City
Nashville
State
TN
Country
United States
Zip Code
37203