Abstract

INTRODUCTION: Increased high-sensitivity c-reactive protein (hs-CRP) is a potent independent predictor of future first cardiac events in healthy adults. However, the determinants of hs-CRP have yet to be clearly defined, and longitudinal data are lacking. PROPOSED STUDY: We have stored sera from a longitudinal study of the seasonal variation in blood cholesterol (SEASON; NHLBI RO1 HL 52745) in which blood samples were collected at baseline, and quarterly for 1 year. This study was entirely observational, subjects were assessed at multiple time points in a free living environment. The data set contains meticulous longitudinal measures of anthropometric characteristics (body mass, BMI, waist: hip ratio), physical activity and dietary intake (12-15 24 hr physical activity and diet recalls), serum lipids and lipoproteins, blood pressure, smoking, ethnicity, socio-economic status, education, demographic factors, recent infection history, and psychological factors. We propose to measure hs-CRP in the stored sera of these subjects, and use the results together with the previously collected data to study the determinants of hs-CRP.
SPECIFIC AIM : To measure hs-CRP in stored sera of healthy men and women (n=621) who participated in the SEASON study (NHLBI RO1 HL 52745) and to examine the determinants of hs-CRP. PRIMARY HYPOTHESIS: BMI will be the strongest predictor of hs-CRP. SECONDARY HYPOTHESES: Dietary glycemic load, omega 3 fatty acid intake, and depression will be secondary determinants of hs-CRP.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21HL076796-02
Application #
6879190
Study Section
Special Emphasis Panel (ZRG1-CCVS (01))
Program Officer
Tolunay, Eser
Project Start
2004-04-01
Project End
2007-03-31
Budget Start
2005-04-01
Budget End
2007-03-31
Support Year
2
Fiscal Year
2005
Total Cost
$79,500
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655

  Publications

Chiriboga, David E; Ma, Yunsheng; Li, Wenjun et al. (2009) Seasonal and sex variation of high-sensitivity C-reactive protein in healthy adults: a longitudinal study. Clin Chem 55:313-21
Griffith, Jennifer A; Ma, Yunsheng; Chasan-Taber, Lisa et al. (2008) Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein. Nutrition 24:401-6
Ma, Yunsheng; Griffith, Jennifer A; Chasan-Taber, Lisa et al. (2006) Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr 83:760-6