This proposal requests funding through an Exploratory Development Grant for Mental Health Intervention Research. Panic disorder (PD) is a highly prevalent and debilitating condition. Research has suggested that cognitive-behavioral therapy (CBT) is a very effective treatment for PD with or without agoraphobia, however, a majority of patients with PD do not receive this type of therapy (or any recommended treatment). Some of the primary factors that limit patient participation in treatment include cost and treatment availability. Self-help treatments are a means to provide low-cost treatment to a much greater number of individuals, and available book-based self-help formats have been found to be effective. Interactive computer-based treatments offer additional advantages over a book-based approach because they are more engaging, thereby leading to greater compliance and decreased attrition. Moreover, computer treatments have the capacity to enhance learning through multiple modalities and interactive features. The purpose of the proposed investigation is to develop an interactive computer-administered version of the most recent genre of CBT treatments for panic disorder (treatment development phase) and to test the efficacy of this type of treatment relative to an established CBT bibliotherapy manual (pilot testing phase). The first phase of this proposal involves developing an interactive computer-based treatment that effectively emulates available CBT protocols for panic disorder. This development will involve translating manualized CBT interventions into a multimedia presentation with various interactive features designed to mimic the type of communication that typically occurs in live CBT. The second phase of this proposal involves refining the computer-administered treatment based on patient utilization from a small, representative sample of patients. Based on patient assessments, the treatment will be redesigned accordingly. The final phase of the proposal involves a clinical trial examining the relative efficacy of the refined computer treatment (about = 20) versus a book-based treatment (about = 20) and a delayed-treatment control group (about = 20). Outcomes will be compared at posttreatment and at 3-month follow-up. It is hypothesized that both active treatment groups will produce better outcomes relative to the control condition and that the computer-based treatment will produce superior outcomes relative to the book-based treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21MH062056-04
Application #
6691708
Study Section
Special Emphasis Panel (ZRG1-BBBP-5 (01))
Program Officer
Street, Linda L
Project Start
2003-07-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2006-12-31
Support Year
4
Fiscal Year
2004
Total Cost
$182,500
Indirect Cost
Name
Florida State University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
790877419
City
Tallahassee
State
FL
Country
United States
Zip Code
32306
Korte, Kristina J; Brown, Marco-Antonio S; Schmidt, Norman B (2013) Anxiety sensitivity and impairment: evidence for a direct association and partial mediation by subclinical anxiety symptoms. J Affect Disord 151:875-81
Capron, Daniel W; Cougle, Jesse R; Ribeiro, Jessica D et al. (2012) An interactive model of anxiety sensitivity relevant to suicide attempt history and future suicidal ideation. J Psychiatr Res 46:174-80
Hazen, Rebecca A; Vasey, Michael W; Schmidt, Norman B (2009) Attentional retraining: a randomized clinical trial for pathological worry. J Psychiatr Res 43:627-33
Timpano, Kiara R; Buckner, Julia D; Richey, J Anthony et al. (2009) Exploration of anxiety sensitivity and distress tolerance as vulnerability factors for hoarding behaviors. Depress Anxiety 26:343-53
Mallott, Michael A; Maner, Jon K; DeWall, Nathan et al. (2009) Compensatory deficits following rejection: the role of social anxiety in disrupting affiliative behavior. Depress Anxiety 26:438-46
Schmidt, Norman B; Timpano, K R; Buckner, Julia D (2008) Fear responding to 35% CO(2) challenge as a vulnerability marker for later social anxiety symptoms. J Psychiatr Res 42:763-8
Schmidt, Norman B; Keough, Meghan E; Timpano, Kiara R et al. (2008) Anxiety sensitivity profile: predictive and incremental validity. J Anxiety Disord 22:1180-9
Schmidt, Norman B; Richey, J Anthony; Zvolensky, Michael J et al. (2008) Exploring human freeze responses to a threat stressor. J Behav Ther Exp Psychiatry 39:292-304
Schmidt, Norman B; Richey, J Anthony (2008) Social anxiety symptoms uniquely predict fear responding to 35% CO(2) challenge. J Psychiatr Res 42:851-7
Feldner, Matthew T; Zvolensky, Michael J; Schmidt, Norman B et al. (2008) A prospective test of anxiety sensitivity as a moderator of the relation between gender and posttraumatic symptom maintenance among high anxiety sensitive young adults. Depress Anxiety 25:190-9

Showing the most recent 10 out of 26 publications