This """"""""developing grant"""""""" application unites a group of 13 productive investigators in order to facilitate translation of basic research on early experience and the development of stress-sensitive neurobiological systems into preventive intervention research with young children who are growing up under conditions of adversity-in particular, children who have experienced maltreatment and relationship disruption. The investigators and pilot studies described herein cover a wide breadth ranging from animal (rodent and non-human primate) research to clinical studies of children in the foster care system. The proposed research will be conducted at 7 research sites, 2 of which involve randomized treatment trials of theoretically driven interventions for at-risk populations of infants and young children. By bringing together this diverse group of investigators we are able to address questions about early experience and stress neurobiology from molecular to social levels of analysis.
The specific aims and the research designs proposed herein are based on 1.5 yrs of initial networking by our group during which time we determined that translational research in this area is likely to be productive, while noting the many questions that still need to be addressed before such research is likely to be successful. Five years of research is proposed, the outcome of which will provide the conceptual and methodological basis needed for studying the impact of early experience on stress neurobiology in randomized treatment interventions designed for infants and young children. As a component of this goal, in addition to the research proposed, we have established a significant training component to this application to enhance integration of prevention/intervention research and developmental neurobiological research in very young children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21MH065046-04
Application #
6800742
Study Section
Special Emphasis Panel (ZMH1-NRB-W (02))
Program Officer
Moscicki, Eve K
Project Start
2001-09-28
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
4
Fiscal Year
2004
Total Cost
$544,827
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Pediatrics
Type
Schools of Education
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Laurent, Heidemarie K; Gilliam, Kathryn S; Wright, Dorianne B et al. (2015) Child anxiety symptoms related to longitudinal cortisol trajectories and acute stress responses: evidence of developmental stress sensitization. J Abnorm Psychol 124:68-79
Laurent, Heidemarie K; Gilliam, Kathryn S; Bruce, Jacqueline et al. (2014) HPA stability for children in foster care: mental health implications and moderation by early intervention. Dev Psychobiol 56:1406-15
Howell, Brittany R; Grand, Alison P; McCormack, Kai M et al. (2014) Early adverse experience increases emotional reactivity in juvenile rhesus macaques: relation to amygdala volume. Dev Psychobiol 56:1735-46
Bruce, Jacqueline; Fisher, Philip A; Graham, Alice M et al. (2013) Patterns of brain activation in foster children and nonmaltreated children during an inhibitory control task. Dev Psychopathol 25:931-41
Hecht, Erin E; Gutman, David A; Preuss, Todd M et al. (2013) Process versus product in social learning: comparative diffusion tensor imaging of neural systems for action execution-observation matching in macaques, chimpanzees, and humans. Cereb Cortex 23:1014-24
Bryck, Richard L; Fisher, Philip A (2012) Training the brain: practical applications of neural plasticity from the intersection of cognitive neuroscience, developmental psychology, and prevention science. Am Psychol 67:87-100
Fisher, Philip A; Van Ryzin, Mark J; Gunnar, Megan R (2011) Mitigating HPA axis dysregulation associated with placement changes in foster care. Psychoneuroendocrinology 36:531-9
Loman, Michelle M; Gunnar, Megan R; Early Experience, Stress, and Neurobehavioral Development Center (2010) Early experience and the development of stress reactivity and regulation in children. Neurosci Biobehav Rev 34:867-76
Bruce, Jacqueline; McDermott, Jennifer Martin; Fisher, Philip A et al. (2009) Using behavioral and electrophysiological measures to assess the effects of a preventive intervention: a preliminary study with preschool-aged foster children. Prev Sci 10:129-40
McCormack, K; Newman, T K; Higley, J D et al. (2009) Serotonin transporter gene variation, infant abuse, and responsiveness to stress in rhesus macaque mothers and infants. Horm Behav 55:538-47

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