Closed head injury (CHI) is a significant public health issue in the US and is associated with impairments in cognitive functioning, particularly in the domain of """"""""executive"""""""" control. The primary aim of this exploratory grant is to examine the componential nature and neural bases of cognitive control dysfunction in CHI.
The specific aims are to: 1) Identify the most critical components of cognitive control dysfunction across the continuum of CHI severity; 2) identify the neural bases of this dysfunction; and 3) determine relationships among cognitive control dysfunction, its neural bases, and manifest symptomatology in CHI. The specific hypotheses motivating the proposed research are that: 1) Patients with acute CHI exhibit severity dependent impairments in at least one of several components of cognitive control (i.e., implementation of cognitive control, detecting processing conflicts, performance monitoring); 2) regions of the frontal cortex mediate this impairment; and 3) aspects of these impairments and associated neural dysfunction are related to patient symptomatic experience. Study methods will examine adult mild, moderate and severe acute CHI patients while performing a novel cognitive task designed to temporally dissociate components of cognitive control in combination with measures of task-related neural activity. High-density event-related potentials will be used to dissociate strategic processes supporting the implementation of cognitive control, and evaluative processes supporting the detection of processing conflicts and performance monitoring. Functional magnetic resonance imaging will be used to identify the neural systems supporting these processes in healthy individuals, and those exhibiting dysfunction in patients with CHI. Self- and other-reported measures of symptom experience will provide information in the domains of cognitive, behavioral and affective expression, which will then be examined for relationships with measures of cognitive control and task-related brain activity. Accomplishing the aims outlined in this proposal will provide the foundation for future longitudinal studies to examine the temporal course of cognitive recovery, the mechanisms of successful intervention, and the design and evaluation of behavioral and pharmacological intervention strategies. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21MH073076-01
Application #
6807998
Study Section
Clinical Neuroscience and Disease Study Section (CND)
Program Officer
Meinecke, Douglas L
Project Start
2004-08-01
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
1
Fiscal Year
2004
Total Cost
$161,026
Indirect Cost
Name
University of Florida
Department
Other Health Professions
Type
Schools of Public Health
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Merkley, Tricia L; Larson, Michael J; Bigler, Erin D et al. (2013) Structural and functional changes of the cingulate gyrus following traumatic brain injury: relation to attention and executive skills. J Int Neuropsychol Soc 19:899-910
Sozda, Christopher N; Larson, Michael J; Kaufman, David A S et al. (2011) Error-related processing following severe traumatic brain injury: an event-related functional magnetic resonance imaging (fMRI) study. Int J Psychophysiol 82:97-106
Larson, Michael J; Fair, Joseph E; Farrer, Thomas J et al. (2011) Predictors of performance monitoring abilities following traumatic brain injury: the influence of negative affect and cognitive sequelae. Int J Psychophysiol 82:61-8
Demery, Jason A; Larson, Michael J; Dixit, Neha K et al. (2010) Operating characteristics of executive functioning tests following traumatic brain injury. Clin Neuropsychol 24:1292-308
Larson, Michael J; Kaufman, David A S; Perlstein, William M (2009) Neural time course of conflict adaptation effects on the Stroop task. Neuropsychologia 47:663-70
Larson, Michael J; Perlstein, William M (2009) Awareness of deficits and error processing after traumatic brain injury. Neuroreport 20:1486-90
Larson, Michael J; Kaufman, David A S; Perlstein, William M (2009) Conflict adaptation and cognitive control adjustments following traumatic brain injury. J Int Neuropsychol Soc 15:927-37
Larson, Michael J; Kaufman, David A S; Kellison, Ida L et al. (2009) Double jeopardy! The additive consequences of negative affect on performance-monitoring decrements following traumatic brain injury. Neuropsychology 23:433-44
Larson, Michael J; Kaufman, David A S; Schmalfuss, Ilona M et al. (2007) Performance monitoring, error processing, and evaluative control following severe TBI. J Int Neuropsychol Soc 13:961-71
Larson, Michael J; Kelly, Kiesa G; Stigge-Kaufman, David A et al. (2007) Reward context sensitivity impairment following severe TBI: an event-related potential investigation. J Int Neuropsychol Soc 13:615-25

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