Abstract

Public Health Relevance

Histone acetylation and deacetylation are epigenetic states that can produce simultaneously activation or silencing of specific genes. Our preliminary studies show that there exist basal differences in the overall degree of acetylation of H3K14 and H2b, but not H4, in rats that differ in response to novelty. We hypothesize that these epigenetic states contribute to individual differences in response to novelty and to individual differences in response to chronic stress-induced psychopathology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21MH081046-01A2
Application #
7659893
Study Section
Neuroendocrinology, Neuroimmunology, and Behavior Study Section (NNB)
Program Officer
Beckel-Mitchener, Andrea C
Project Start
2009-04-07
Project End
2011-03-31
Budget Start
2009-04-07
Budget End
2010-03-31
Support Year
1
Fiscal Year
2009
Total Cost
$217,377
Indirect Cost

  Institution

Name
Florida State University
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
790877419
City
Tallahassee
State
FL
Country
United States
Zip Code
32306

  Publications

Duclot, Florian; Kabbaj, Mohamed (2015) Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. J Exp Biol 218:21-31
Duclot, Florian; Kabbaj, Mohamed (2013) Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. J Neurosci 33:11048-60
Hollis, F; Gaval-Cruz, M; Carrier, N et al. (2012) Juvenile and adult rats differ in cocaine reward and expression of zif268 in the forebrain. Neuroscience 200:91-8
Radley, Jason J; Kabbaj, Mohamed; Jacobson, Lauren et al. (2011) Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypes. Stress 14:481-97
Singh, Rakesh Kumar; Gunjan, Akash (2011) Histone tyrosine phosphorylation comes of age. Epigenetics 6:153-60
Hollis, F; Duclot, F; Gunjan, A et al. (2011) Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus. Horm Behav 59:331-7
Duclot, Florian; Hollis, Fiona; Darcy, Michael J et al. (2011) Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders. Physiol Behav 104:296-305
Hollis, Fiona; Wang, Hui; Dietz, David et al. (2010) The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague-Dawley rats. Psychopharmacology (Berl) 211:69-77
Singh, Rakesh Kumar; Liang, Dun; Gajjalaiahvari, Ugander Reddy et al. (2010) Excess histone levels mediate cytotoxicity via multiple mechanisms. Cell Cycle 9:4236-44