Being involved in combat is a horrific experience that substantially increases the risk of developing posttraumatic stress disorder (PTSD). Although several effective treatments have been identified for PTSD a substantial number of patients (up to 50%) continue to experience symptoms. In fact, combat related PTSD is even less responsive to existing treatments than PTSD caused by other traumatic experiences. In short, the treatment for chronic PTSD is inadequate. The field of neuroscience has revealed that patients with PTSD demonstrate altered functioning within, and interactions between, several brain regions;findings that are consistent with animal models of chronic stress. Despite this evidence, existing treatments are generally not designed using this neuroanatomical knowledge. The central premise of the proposed study is that neuroscientifically-based information can be used to develop more precise and effective treatments. High definition transcranial direct current stimulation (HD-tDCS) will be used to """"""""correct"""""""" the dysfunctional brain regions (and communication between these regions), with the expectation that this modulation will result in symptom improvement. The primary goals of the proposed R21/R33 are to verify the maladaptive brain networks and then establish evidence that HD-tDCS modulates these networks (R21 phase). Latter studies (R33 phase) will examine dose-response relationships and synergistic effects of HD-tDCS and existing treatments. In both phases, outcome will be assessed using a multi-method approach that includes functional connectivity using resting-state functional magnetic resonance imaging data, neuropsychological tests, and self-report measures of emotional functioning. The combined results will provide vital methodological, mechanistic, and practical information necessary for a formal clinical trial of tDCS in PTSD. Ultimately, the proposed approach could reinforce a fundamental shift in the development and implementation of treatments for mental illnesses that share common core features, which is consistent with the NIMH's Strategic Plans to classify and treat mental disorders using behavioral dimensions and neurobiological measures.

Public Health Relevance

Current treatments for posttraumatic stress disorder (PTSD) can be improved, especially for those with combat related PTSD. This study will target specific brain regions that are altered in those with PTSD and use non-invasive brain stimulation to correctively alter functioning in these regions. This approach may ultimately provide a more effective treatment for PTSD that could be used on its own or in combination with established treatments.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Exploratory/Developmental Grants (R21)
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Study Section
Special Emphasis Panel (ZMH1)
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Tuma, Farris K
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University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
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Reckow, Jaclyn; Rahman-Filipiak, Annalise; Garcia, Sarah et al. (2018) Tolerability and blinding of 4x1 high-definition transcranial direct current stimulation (HD-tDCS) at two and three milliamps. Brain Stimul 11:991-997
Hampstead, Benjamin M; BriceƱo, Emily M; Mascaro, Nathan et al. (2016) Current Status of Transcranial Direct Current Stimulation in Posttraumatic Stress and Other Anxiety Disorders. Curr Behav Neurosci Rep 3:95-101