Stress is a complex medical problem in which psychological, social, cultural, and physiological factors all can interact in the development of illness. Stress-related health problems are endemic, and can take on any number of medical or psychiatric forms. This grant proposal describes a plan for the development of a new multidisciplinary mind-body center at NYU dedicated to basic, clinical, and translational research in stress and health. The unifying scientific themes of this center focus on the interactions of psychosocial stress, limbic brain, the neuroendocrine stress response (particularly the hypothalamic-pituitary-adrenal axis and the sympathoadrenergic system) and the downstream effects of the stress response on physical and mental functioning. Other themes of this center include understanding the maladaptive stress-induced behaviors that worsen stress and health, as well as coping mechanisms and other protective factors that ameliorate the health effects of stress. The goal of this center is to build an intellectual environment in which program scientists from a variety of fields can meet for the free exchange of ideas and to develop standardized batteries of assessments for use in interdisciplinary research projects. An Administrative Core would organize center activities and funds, and would be responsible for data management. A Research Core would bring together program scientists and resources, and would be governed by committee. Pilot projects would serve as the starting point for the development of central standardized resources, including clinical protocols, basic science methods, and neuroimaging protocols. A Training & Development Core would provide cross-disciplinary training for group members and a forum for young researchers and clinicians to learn about research in stress and health, and to interact closely with senior investigators. Educational goals of the center include community and trainee outreach and annual conferences. The long-term vision for the proposed center is one in which ongoing interdisciplinary longitudinal studies of stress and health would coexist with individual research projects that utilize the same shared resources. Such an infrastructure would promote greater knowledge among individual researchers and would enrich the field of stress research by providing a regular forum for the discussion of research issues and plans for future projects. This infrastructure also would improve research cost efficiency by preventing study duplication, providing a centralized shared resources, and having an intrinsic system of checks and balances within the governing committee. ? ?

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Exploratory/Developmental Grants (R21)
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Study Section
Special Emphasis Panel (ZRG1-RPHB-B (51))
Program Officer
Babcock, Debra J
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New York University
Schools of Medicine
New York
United States
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Solomon, Todd M; Kiang, Mathew V; Halkitis, Perry N et al. (2010) Personality traits and mental health states of methamphetamine-dependent and methamphetamine non-using MSM. Addict Behav 35:161-3
Ring, Sabine; Oliver, Stephen J; Cronstein, Bruce N et al. (2009) CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism. J Allergy Clin Immunol 123:1287-96.e2
Halkitis, Perry N; Solomon, Todd M; Moeller, Robert W et al. (2009) Methamphetamine use among gay, bisexual and non-identified men-who-have-sex-with-men: an analysis of daily patterns. J Health Psychol 14:222-31
Arentoft, Alyssa; Sweat, Victoria; Starr, Vanessa et al. (2009) Plasma BDNF is reduced among middle-aged and elderly women with impaired insulin function: evidence of a compensatory mechanism. Brain Cogn 71:147-52
Goetz, Christopher G; Laska, Eugene; Hicking, Christine et al. (2008) Placebo influences on dyskinesia in Parkinson's disease. Mov Disord 23:700-7
Stone, Eric A; Lin, Yan; Quartermain, David (2008) Evaluation of the repeated open-space swim model of depression in the mouse. Pharmacol Biochem Behav 91:190-5
Stone, Eric A; Lin, Yan (2008) An anti-immobility effect of exogenous corticosterone in mice. Eur J Pharmacol 580:135-42
Stone, Eric A; Lin, Yan; Quartermain, David (2008) A final common pathway for depression? Progress toward a general conceptual framework. Neurosci Biobehav Rev 32:508-24
Stone, Eric A; Lehmann, Michael L; Lin, Yan et al. (2007) Reduced evoked fos expression in activity-related brain regions in animal models of behavioral depression. Prog Neuropsychopharmacol Biol Psychiatry 31:1196-207
Stone, Eric A; Quartermain, David; Lin, Yan et al. (2007) Central alpha1-adrenergic system in behavioral activity and depression. Biochem Pharmacol 73:1063-75

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