Hypoxic-ischemic encephalopathy (HIE) damages premature white matter and gray matter in infants and causes significant mortality and morbidity. To find satisfactory treatments, animal models of HIE have been established and widely used. In this project, novel magnetic resonance imaging techniques will be developed to examine temporal evolution of brain injury in a neonatal mouse model of HIE. Focus will be placed on the development of fast imaging techniques for monitoring injuries in neonatal animals, and new template based techniques to assess the extent and progression of brain injury, especially in the developing white matter.
In aim #1, we will develop an in vivo neonatal mouse imaging system.
In aim #2, we will develop template based techniques to assess gray and white matter injuries.
In aim #3, we will evaluate tract specific injuries caused by HIE. We will use these techniques to characterize the temporal evolution of gray and white matter injuries in neonatal mice with HIE and correlate the results with pathology. The results will provide key information for study of HIE, and the techniques can be applied to other animal models. In summary, this proposal will establish a model imaging system for exploration of novel treatments of hypoxic-ischemic encephalopathy.
Hypoxic-ischemic encephalopathy (HIE) causes significant mortality and morbidity in infants. In this project, novel magnetic resonance imaging techniques will be developed to examine temporal evolution of brain injury in a neonatal mouse model of HIE, for exploration of novel treatments of hypoxic-ischemic encephalopathy. ? ? ?
| van der Aa, Niek E; Northington, Frances J; Stone, Brian S et al. (2013) Quantification of white matter injury following neonatal stroke with serial DTI. Pediatr Res 73:756-62 |
| Wu, Dan; Xu, Jiadi; McMahon, Michael T et al. (2013) In vivo high-resolution diffusion tensor imaging of the mouse brain. Neuroimage 83:18-26 |
| Aggarwal, Manisha; Jones, Melina V; Calabresi, Peter A et al. (2012) Probing mouse brain microstructure using oscillating gradient diffusion MRI. Magn Reson Med 67:98-109 |
| Zhang, Jiangyang; Aggarwal, Manisha; Mori, Susumu (2012) Structural insights into the rodent CNS via diffusion tensor imaging. Trends Neurosci 35:412-21 |
| Zhang, Jiangyang; Jones, Melina V; McMahon, Michael T et al. (2012) In vivo and ex vivo diffusion tensor imaging of cuprizone-induced demyelination in the mouse corpus callosum. Magn Reson Med 67:750-9 |
| Chavez-Valdez, R; Martin, L J; Flock, D L et al. (2012) Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia. Neuroscience 219:192-203 |
| Byrnes, Kimberly R; Loane, David J; Stoica, Bogdan A et al. (2012) Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. J Neuroinflammation 9:43 |
| Chuang, Nelson; Mori, Susumu; Yamamoto, Akira et al. (2011) An MRI-based atlas and database of the developing mouse brain. Neuroimage 54:80-9 |
| Northington, Frances J; Chavez-Valdez, Raul; Martin, Lee J (2011) Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol 69:743-58 |
| Lopez, Pablo H H; Ahmad, Abdullah S; Mehta, Niraj R et al. (2011) Myelin-associated glycoprotein protects neurons from excitotoxicity. J Neurochem 116:900-8 |
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