Abstract

This research proposal is intended to identify and initially characterize events involved in the pathogenesis of lymphatic lesions produced by filarial nematodes. Brugia pahangi infections of mongolian jirds (Meriones unquiculatus) will be used as an animal model.
The specific aims of the proposal will investigate the role of specific host immune effectors such as lymphocytes, and antibody and nonspecific effectors such as macrophages in the induction and/or modulation of these lesions. In addition, attempts will be made to further develop the in vivo model using the B. pahangi jird system to characterize in detail the events involved in development, maintenance and modulation of filarial induced granulomatous lesions. Obtaining the goals of this project would advance the understanding of the pathogenesis of lymphatic filariasis and thus, increase in the future, the feasibility of the control and amelioration of the tissue damaging lesions produced by these parasites.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Unknown (R22)
Project #
5R22AI019199-02
Application #
3444607
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1984-03-01
Project End
1987-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University A&M Col Baton Rouge
Department
Type
Schools of Veterinary Medicine
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803

  Publications

Chirgwin, Sharon R; Coleman, Sharon U; Porthouse, Kristina H et al. (2006) Tissue migration capability of larval and adult Brugia pahangi. J Parasitol 92:46-51
Porthouse, Kristina H; Chirgwin, Sharon R; Coleman, Sharon U et al. (2006) Inflammatory responses to migrating Brugia pahangi third-stage larvae. Infect Immun 74:2366-72
Chirgwin, S R; Rao, U R; Mai, Z et al. (2005) Kinetics of T cell cytokine gene expression in gerbils after a primary subcutaneous Brugia pahangi infection. J Parasitol 91:264-8
Chirgwin, S R; Rao, U R; Coleman, S U et al. (2005) Profiling the cellular immune response to multiple Brugia pahangi infections in a susceptible host. J Parasitol 91:822-9
Chirgwin, Sharon R; Nowling, Jena M; Coleman, Sharon U et al. (2003) Effect of immunostimulatory oligodeoxynucleotides on host responses and the establishment of Brugia pahangi in Mongolian gerbils (Meriones unguiculatus). J Parasitol 89:483-9
Chirgwin, Sharon R; Coleman, Sharon U; Porthouse, Kristina H et al. (2003) Removal of Wolbachia from Brugia pahangi is closely linked to worm death and fecundity but does not result in altered lymphatic lesion formation in Mongolian gerbils (Meriones unguiculatus). Infect Immun 71:6986-94
Chirgwin, Sharon R; Nowling, Jena M; Coleman, Sharon U et al. (2003) Brugia pahangi and Wolbachia: the kinetics of bacteria elimination, worm viability, and host responses following tetracycline treatment. Exp Parasitol 103:16-26
Chirgwin, S R; Porthouse, K H; Nowling, J M et al. (2002) The filarial endosymbiont Wolbachia sp. is absent from Setaria equina. J Parasitol 88:1248-50
Chirgwin, Sharon R; Elzer, Philip H; Coleman, Sharon U et al. (2002) Infection outcome and cytokine gene expression in Brugia pahangi- infected gerbils (Meriones unguiculatus) sensitized with Brucella abortus. Infect Immun 70:5938-45
Rao, U R; Nasarre, C; Coleman, S U et al. (1999) Granulomatous inflammatory response to recombinant filarial proteins of Brugia species. Am J Trop Med Hyg 60:251-4

Showing the most recent 10 out of 29 publications