The specific aims of the proposed research are to further identify and characterize those host components which are bound to the schistosome tegumental surface and to ascertain the specificity of that binding, to compare the structure of the freshly harvested tegumental membrane with that of a host antigen depleted or cytochemically labeled parasite, to examine the dynamic nature of the tegumental surface with the goal of determining the extent of control the parasite exercises over its surface, and to assess the role of the tegumental cytoskeleton in regulating surface phenomena.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Unknown (R22)
Project #
5R22AI021839-02
Application #
3444762
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1986-09-01
Project End
1989-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Texas A&M University
Department
Type
Schools of Arts and Sciences
DUNS #
City
College Station
State
TX
Country
United States
Zip Code
77845
Gearner, G W; Kemp, W M (1994) Electrophoretic and serological analysis of host antigens associated with the adult Schistosoma mansoni tegument. J Parasitol 80:275-83
Neill, P J; Smith, J H; Doughty, B L et al. (1988) The ultrastructure of the Schistosoma mansoni egg. Am J Trop Med Hyg 39:52-65