The specific plan of this research proposal is to identify important mutagenicity/toxicity test systems along with the corresponding currently employed analysis procedures and subject them to a thorough evaluation from a statistical perspective. The main goal of this research is to improve the reliability and efficiency of such health related research by improving the statistical validity of the analysis procedures and by determining the optimal design configurations for performing the experiments. Preliminary efforts in this direction suggest that such improvements can generally be made resulting in better test performance (fewer false conclusions) and less expensive experiments (reduced sample size requirements).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Unknown (R23)
Project #
5R23ES003254-02
Application #
3447635
Study Section
(SSS)
Project Start
1984-01-01
Project End
1986-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Montana State University Bozeman
Department
Type
Schools of Arts and Sciences
DUNS #
City
Bozeman
State
MT
Country
United States
Zip Code
59717
Collings, B J; Hamilton, M A (1988) Estimating the power of the two-sample Wilcoxon test for location shift. Biometrics 44:847-60