The purpose of the proposed studies is to examine the mechanisms that have been postulated to increase the pulmonary vascular permeability to fluid and proteins during activation of the complement system. Studies will be made in sheep in which pulmonary lymph will be collected to assess alterations in pulmonary fluid and protein exchange. These studies will examine the contributions of the putative factors postulated to increase vascular permeability after complement activation induced with cobra venom factor or zymosan activated plasma. The participation of fibrinogen, leukocytes, and platelets will be assessed by depletion studies. The roles of oxygen radicals, and plasmin, will be examined by preventing their formation during complement activation. The postulated roles of TxA2, PGI2, PGE2, and alveolar hypoxia in modulating the degree of lung vascular injury after complement activation will also be examined. These studies will help to elucidate the mechanism of increased vascular permeability after complement activation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Unknown (R23)
Project #
5R23HL031359-03
Application #
3448587
Study Section
Pathology A Study Section (PTHA)
Project Start
1984-07-01
Project End
1987-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Albany Medical College
Department
Type
Schools of Medicine
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12208