Abstract

One of the major risk factors for the development of atherosclerosis is the concentration of lipoproteins in serum. Knowledge of the genetic factors that influence this risk factor is importnat for the understanding of the etiology of atherosclerosis. The overall aim of this proposal is to seek genetic factors influencing lipoprotein phenotypes in an animal model for atherosclerosis, the baboon. The baboon is an excellent animal model for atherosclerosis because its physiological, pathophysiological, and biochemical characteristics are similar to those of humans. I will derive lipoprotein phenotypes from several sources of data (i.e., serum cholesterol concentrations, lipoprotein profiles obtained from polyacrylamide gradient gel electrophoresis and high-pressure liquid chromatography), that are available on 790 pedigreed baboons. Then I will perform genetic analyses on these phenotypes using two preliminary methods of genetic analysis, sibship variance tests and Structured Exploratory Data Analysis, and one method of complex segregation analysis, PAP. I also will perform computer simulations to empirically estimate the power of these methods, which were developed for use on human pedigree data, on data from pedigree structures that are common in animal models of human disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Unknown (R23)
Project #
5R23HL035444-02
Application #
3449118
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1986-01-08
Project End
1988-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245

  Publications

Crippa, Fulvio; Holmberg, Leona; Carter, Rachel A et al. (2002) Infectious complications after autologous CD34-selected peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 8:281-9
Hixson, J E; Kammerer, C M; Cox, L A et al. (1989) Identification of LDL receptor gene marker associated with altered levels of LDL cholesterol and apolipoprotein B in baboons. Arteriosclerosis 9:829-35
MacCluer, J W; Kammerer, C M; Blangero, J et al. (1988) Pedigree analysis of HDL cholesterol concentration in baboons on two diets. Am J Hum Genet 43:401-13
MacCluer, J W; Kammerer, C M; VandeBerg, J L et al. (1987) Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings. Genetica 73:159-68