There has been a dramatic increase in interest in noninvasive imaging of small animal tumor models at the University of Michigan over the past several years. In order to assist investigators with imaging requirements, a Magnetic Resonance Imaging (MRI) and Digital Image Processing Laboratory (DIPL) were developed as part of the University of Michigan Comprehensive Cancer Center Core Facilities. The MRI and DIPL core labs are currently available to assist a limited number of investigators with acquisition of imaging data and post processing. The interest in this technology has outgrown both the capabilities of the equipment as well as the number of laboratory personnel. The objectives of this proposal are to: 1) Update and expand the capabilities of our 2T and 7T horizontal bore animal MR imaging and spectroscopy systems (MRI/S) including adding microimaging capabilities of our 2T and 7T horizontal bore animal MR imaging and spectroscopy systems (MRI/S) including adding microimaging capabilities for high-resolution mouse tumor imaging. 2) Acquire a miniature x-ray computed tomography (CT) device capable of scanning both mice and rats. 3) Provide the capability to obtain quantitative autoradiographic data of tumors for correlation and comparison with MRI/S and CT data. 4) Increase the number of personnel available to assist investigators with these technologies. 5) Develop and implement new imaging and post processing capabilities to enhance the quantitative analysis of imaging data. 6) Provide opportunities for women, minority and young investigators to use these facilities through consultation with relevant personnel and small seed grants. 7) Initiate a quarterly seminar series open to all scientists to encourage interactions and exchange of ideas. These objectives were defined to bring the University of Michigan small animal especially important since our current user base encompasses many faculty at the University of Michigan and other academic institutions in Michigan, Wisconsin, Minnesota, as well as an investigator at a local company with NIH SBIR funding for cancer research. The overall goal of this proposal will be to provide a shared resource to improve the tool that cancer researchers can utilize to pursue their individual research interests. Significantly improving the capabilities and throughput of our imaging facilitate will give more investigators access to these technologies and will provide a more diverse and dynamic exchange of techniques and ideas. This type of interaction will surely foster interdisciplinary collaborations in cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects (R24)
Project #
5R24CA083099-03
Application #
6377483
Study Section
Special Emphasis Panel (ZCA1-SRRB-3 (M2))
Project Start
1999-09-01
Project End
2004-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
3
Fiscal Year
2001
Total Cost
$434,468
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Keith, Lauren; Ross, Brian D; Galbán, Craig J et al. (2016) Semiautomated Workflow for Clinically Streamlined Glioma Parametric Response Mapping. Tomography 2:267-275
Luker, K E; Lewin, S A; Mihalko, L A et al. (2012) Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells. Oncogene 31:4750-8
Schinske, Katrina A; Nyati, Shyam; Khan, Amjad P et al. (2011) A novel kinase inhibitor of FADD phosphorylation chemosensitizes through the inhibition of NF-?B. Mol Cancer Ther 10:1807-17
Luker, Kathryn E; Luker, Gary D (2010) Bioluminescence imaging of reporter mice for studies of infection and inflammation. Antiviral Res 86:93-100
Kwee, Thomas C; Galban, Craig J; Tsien, Christina et al. (2010) Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas. J Magn Reson Imaging 31:531-7
Kesisoglou, Filippos; Schmiedlin-Ren, Phyllissa; Fleisher, David et al. (2010) Adenoviral transduction of enterocytes and M-cells using in vitro models based on Caco-2 cells: the coxsackievirus and adenovirus receptor (CAR) mediates both apical and basolateral transduction. Mol Pharm 7:619-29
Galban, Craig J; Bhojani, Mahaveer S; Lee, Kuei C et al. (2010) Evaluation of treatment-associated inflammatory response on diffusion-weighted magnetic resonance imaging and 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging biomarkers. Clin Cancer Res 16:1542-52
Khanna, Divya; Hamilton, Christin A; Bhojani, Mahaveer S et al. (2010) A transgenic mouse for imaging caspase-dependent apoptosis within the skin. J Invest Dermatol 130:1797-806
Kwee, Thomas C; Galbán, Craig J; Tsien, Christina et al. (2010) Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas. NMR Biomed 23:179-87
Galbán, Craig J; Galbán, Stefanie; Van Dort, Marcian E et al. (2010) Applications of molecular imaging. Prog Mol Biol Transl Sci 95:237-98

Showing the most recent 10 out of 78 publications