The overall goal of this proposal is to establish a DNA Microarray and Bioinformatics Resource Facility at the Hollings Cancer Center (HCC), Medical University of South Carolina. The planned NCI-funded resource facility will build upon recent institutional investments and create a comprehensive infrastructure comprised of faculty, support staff, state-of-the-art instrumentation and advanced computational/statistical analysis resources required to facilitate the use of DNA microarray analysis to identify profiles of genes expressed in specific cancer-related processes. Major goals of the proposal include providing investigators with expert consultation and assistance through all critical phases of the process of DNA microarray analysis including the initial experimental planning phase, molecular biology phase and through to the data analysis phase. The latter will involve implementation of both commercial software applications as well as a number of advanced computer algorithms developed by bioinformatics specialists supported through the core. Finally, the resource facility will create an internet-accessible database of gene expression profile information collected by HCC investigators to make this data available to the scientific community at large.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects (R24)
Project #
5R24CA095841-05
Application #
7048595
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (J2))
Program Officer
Couch, Jennifer A
Project Start
2002-04-01
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
5
Fiscal Year
2006
Total Cost
$239,195
Indirect Cost
Name
Medical University of South Carolina
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
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