The long-range goal of the proposed DIDARP program described in this application is to continue to increase the capacity of Meharry Medical College to conduct rigorous research in substance use disorders with an [ emphasis on health disparities and underserved populations. The research program will seek to understand the molecular underpinnings of acute and chronic methamphetamine (METH) exposure alone and in conjunction with human immunodeficiency virus (HIV) infection. We also plan to strengthen pur intellectual environment and enhance the interest levels of trainees and faculty in drug abuse research. New for this j application is the proposal to introduce training on screening and brief interventions for substance misuse to medical students, residents and faculty in the Family and Community Medicine clinics.
The Specific Aims of the Meharry Medical College DIDARP Program during the next five years are: 1. To publish at least 20 or more peer-reviewed publications in high-impact journals in drug abuse research; 2. To submit 5 or more grant applications in drug abuse research by Year-03 of the award period; | 3. To acquire 3 or more investigator-initiated awards by the end of year-05; and 4. To stimulate additional faculty and trainee interest in drug abuse research by curricula enhancement, ' seminars and symposia. . Three projects are proposed, one primary proposal and two pilot projects. In the primary project, Dr. CV. ] Dash will seek to understand the link between METH abuse and HIV infection. In the first pilot project, Dr. J. Shawn Goodwin will study how METH abuse alters dopamine signaling by altering the dopamine transporter residency in lipid rafts. In second pilot project, Dr. Khilber and her collaborators which includes the PI and the Chair of Family and Community Medicine, Dr. Roger Zoorob, will test the effects of a tiered training program on screening, brief intervention and referral to treatment (SBIRT) for substance misuse fo

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Resource-Related Research Projects (R24)
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Special Emphasis Panel (ZDA1-NXR-B (14))
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Lin, Yu
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Meharry Medical College
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United States
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Dash, Sabyasachi; Balasubramaniam, Muthukumar; Dash, Chandravanu et al. (2018) Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs. J Vis Exp :
Dong, Xin-Hong; Ho, Meng-Hsuan; Liu, Bindong et al. (2018) Role of Porphyromonas gingivalis outer membrane vesicles in oral mucosal transmission of HIV. Sci Rep 8:8812
Burroughs, Andrea Flores; Eluhu, Sylvia; Whalen, Diva et al. (2018) PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus. Cell Physiol Biochem 47:800-816
Abney, Kristopher K; Ramos-Hunter, Susan J; Romaine, Ian M et al. (2018) Selective Activation of N,N'-Diacyl Rhodamine Pro-fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE). Chemistry 24:8985-8988
Balasubramaniam, Muthukumar; Pandhare, Jui; Dash, Chandravanu (2018) Are microRNAs Important Players in HIV-1 Infection? An Update. Viruses 10:
Welch, Jennifer L; Madison, Marisa N; Margolick, Joseph B et al. (2017) Effect of prolonged freezing of semen on exosome recovery and biologic activity. Sci Rep 7:45034
Dash, Sabyasachi; Balasubramaniam, Muthukumar; Rana, Tanu et al. (2017) Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b. eNeuro 4:
Xie, Yingqiu; Lu, Wenfu; Liu, Shenji et al. (2016) MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo. Oncotarget 7:47609-47619
Ho, Meng-Hsuan; Huang, Li; Goodwin, J Shawn et al. (2016) Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis. PLoS One 11:e0149618
Yang, Fang; Yang, Hong; Ramesh, Aramandla et al. (2016) Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. PLoS One 11:e0162561

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