This Biomedical Research Partnership proposal represents a multidisciplinary approach to advance the state of the art in diagnostic anatomical and functional imaging in situ at the micron scale. This will be achieved by developing fundamental advances in the technology of Optical Coherence Tomography, validating new techniques using animal models, and employing new technologies in pilot clinical studies. The Partnership includes biomedical engineers and clinicians from five institutions with demonstrated leadership in the transfer of optical diagnostic technologies to clinical practice.
The specific aims of the proposal and the institutions involved in each (abbreviations found below) are: 1. To enhance and expand the clinical utility of Optical Coherence Tomography by developing the following core technologies: I) high frame rate imaging, ii) ultrahigh resolution imaging, iii) minimally invasive endoscopic and ophthalmic delivery systems, and iv) imaging of physiological function including blood flow and tissue hydration (CWRU-BME). 2. To apply these technologies for pilot studies of early cancer detection in the gastrointestinal tract (CWRU MED, CWRU-BME). 3. To apply these technologies for studies of chemoprevention and early cancer detection in the lung (BCCA, CWRU-BME). 4. To improve the accuracy and safety of keratorefractive surgery by developing OCT technology to measure the corneal epithelial remodeling response, structural stability, and hydration changes following laser in-situ keratomileusis (LASIK) (CCFEI), CWRU-BME). 5. To improve imaging of retinal, sub-retinal, and vitreous pathologies with increased resolution and reduced motion artifacts (CCFEI, DUEC,CWRU-BME). 6. To apply functional imaging technologies for the quantitative detection of retinal/choroidal blood flow and vitreoretinal strand motion in animals and humans, and to apply these technologies to monitor patients with vascular complications of diabetes, glaucoma, age related macular degeneration, and retinal occlusive disease (NU, CCF, DUEC, CWRU-BME); and patients with vitreomacular interface abnormalities (DUEC). By the end of the first year of the project, all Partners will have state of the art faciliti4es for optical coherence tomography research and will be engaged in in vitro or in vivo studies related to endoscopic/bronchosopic cancer imaging or ophthalmic diagnosis. Technical innovations developed at the grantee and Partner institutions will be rapidly shared among the Partnership; clinical study results will lead to a new technology optimization through regular interactions between Partnership personnel.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Resource-Related Research Projects (R24)
Project #
1R24EY013015-01
Application #
6053363
Study Section
Special Emphasis Panel (ZRG1-SRB (02))
Program Officer
Croft, Barbara
Project Start
1999-09-30
Project End
2004-09-29
Budget Start
1999-09-30
Budget End
2000-09-29
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Li, Yan; Lowder, Careen; Zhang, Xinbo et al. (2013) Anterior chamber cell grading by optical coherence tomography. Invest Ophthalmol Vis Sci 54:258-65
Nguyen, Pho; Huang, David; Li, Yan et al. (2012) Correlation between optical coherence tomography-derived assessments of lower tear meniscus parameters and clinical features of dry eye disease. Cornea 31:680-5
Tittler, Ethan H; Bujak, Matthew C; Nguyen, Pho et al. (2011) Between-grader repeatability of tear meniscus measurements using Fourier-domain OCT in patients with dry eye. Ophthalmic Surg Lasers Imaging 42:423-7
Bujak, Matthew C; Yiu, Samuel; Zhang, Xinbo et al. (2011) Serial measurement of tear meniscus by FD-OCT after instillation of artificial tears in patients with dry eyes. Ophthalmic Surg Lasers Imaging 42:308-13
Li, Yan; Tang, Maolong; Zhang, Xinbo et al. (2010) Pachymetric mapping with Fourier-domain optical coherence tomography. J Cataract Refract Surg 36:826-31
Memarzadeh, Farnaz; Li, Yan; Chopra, Vikas et al. (2007) Anterior segment optical coherence tomography for imaging the anterior chamber after laser peripheral iridotomy. Am J Ophthalmol 143:877-9
Lin, Roger C; Li, Yan; Tang, Maolong et al. (2007) Screening for previous refractive surgery in eye bank corneas by using optical coherence tomography. Cornea 26:594-9
Li, Yan; Netto, Marcelo V; Shekhar, Raj et al. (2007) A longitudinal study of LASIK flap and stromal thickness with high-speed optical coherence tomography. Ophthalmology 114:1124-32
Memarzadeh, Farnaz; Li, Yan; Francis, Brian A et al. (2007) Optical coherence tomography of the anterior segment in secondary glaucoma with corneal opacity after penetrating keratoplasty. Br J Ophthalmol 91:189-92
Bakri, Sophie; Singh, Arun D; Lowder, Careen Y et al. (2007) Imaging of iris lesions with high-speed optical coherence tomography. Ophthalmic Surg Lasers Imaging 38:27-34

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