Abstract

The goal of the proposal is to continue to maintain and upgrade the LIPID MAPS Lipidomics Gateway website for a 3-year period following the termination of the NIGMS glue-grant in August 2013. Specifically, we plan to host the Lipidomics Gateway website as a full-featured, user-friendly online resource for the research and academic sectors by actively maintaining and updating the lipid structure and lipid-related gene/protein databases, by maintaining all integrated biochemical and signaling pathways on the website, by continuing to host all legacy experimental data acquired and processed over the lifetime of the LIPID MAPS grant, including all relevant procedures, protocols and standards libraries and by maintaining and upgrading the suite of online mass spectrometry search and prediction tools to provide an integrated search and reference resource for lipidomics MS researchers.

Public Health Relevance

The LIPID MAPS Lipidomics Gateway web resource is the first of its kind that provides a comprehensive list of lipids and associated genes and proteins, along with quantitative metrics and context specific cellular networks of lipids. This is an enormously valuable resource for the community and the present proposal will aim towards disseminating this resource and developing a sun downing strategy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Resource-Related Research Projects (R24)
Project #
1R24GM107784-01
Application #
8575136
Study Section
Special Emphasis Panel (ZGM1-PPBC-5 (LG))
Program Officer
Chin, Jean
Project Start
2013-09-01
Project End
2016-07-31
Budget Start
2013-09-01
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$503,752
Indirect Cost
$178,751

  Institution

Name
University of California San Diego
Department
Engineering (All Types)
Type
Schools of Arts and Sciences
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Gorden, D Lee; Myers, David S; Ivanova, Pavlina T et al. (2015) Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res 56:722-36
Dinasarapu, Ashok Reddy; Gupta, Shakti; Ram Maurya, Mano et al. (2013) A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism. Bioinformatics 29:2735-43
Maurya, Mano R; Gupta, Shakti; Li, Xiang et al. (2013) Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. J Lipid Res 54:2525-42
Shibata, Norihito; Carlin, Aaron F; Spann, Nathanael J et al. (2013) 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem 288:35812-23
Merrill, Alfred H; Dennis, Edward A; McDonald, Jeffrey G et al. (2013) Lipidomics technologies at the end of the first decade and the beginning of the next. Adv Nutr 4:565-7