The goal of the proposed R24 program is the implementation of a transition plan for several legacy resources acquired during the 11-year NIGMS P50 funding period for the Center for Chemical Methodology and Library Development at Boston University (CMLD-BU). This work will support important, NIGMS-funded legacy resources that continue to be of high value to the community of researchers that NIGMS supports. Under the leadership of Professor Porco and coworkers, these materials, tools and services will continue to ensure timely, high quality and cost-efficient progress at the critical interface of synthetic chemistry and biomedical research. CMLD-BU resources have been fully integrated into the Boston University Center for Molecular Discovery (BU- CMD), a new functional center enabling translational biomedical research. This R24 transition involves the repurposing of key CMLD infrastructure and staff with the goal of supporting the continued distribution of small molecules to biological investigators and ensuring sustained access to critical pieces of instrumentation for small molecule synthesis, purification, and analysis. The Principal Investigator, Professor John Porco, and colleagues will oversee the incorporation of existing center assets to a self-sustaining, service-based center. The proposed plan involves reorganizing the center into three functional cores with a focus on achieving the following aims: Maintenance and replenishment of the CMLD-BU legacy compound collection within the Compound Synthesis Core (CSC). Continued distribution of the legacy compound collection to biological researchers for high-throughput screening (HTS) within the BU-CMD Chemical Library Consortium (CLC). Establishment of the Instrumentation Core (IC) and Purification & Curation Core (PCC) as self-sustaining, open-access cost recovery centers for use by the synthetic organic chemistry community. Design and implementation of a three-year transitional plan for self-sustainability with accompanying evaluative metrics.

Public Health Relevance

The goal of the proposed program is to maintain the existing legacy resources of the Center for Chemical Methodology and Library Development (CMLD-BU) to ensure continued availability of the center's screening collections, key services, and instrumentation to the scientific community. We have recently transitioned CMLD-BU assets to the Boston University Center for Molecular Discovery (BU-CMD), and propose a plan to ensure the prolonged viability of these key NIH-funded investments. These assets will continue to enable scientists engaging in basic research as well as facilitate biomedical discoveries at the interface of chemistry and biology leading to the improvement of human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Resource-Related Research Projects (R24)
Project #
1R24GM111625-01A1
Application #
8951968
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Fabian, Miles
Project Start
2015-07-01
Project End
2018-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Boston University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
Wu, Xiaowei; Iwata, Takayuki; Scharf, Adam et al. (2018) Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling. J Am Chem Soc 140:5969-5975
Yang, Xiaoxuan; Jounaidi, Youssef; Dai, Jennifer B et al. (2018) High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology 129:459-476
Qi, Chao; Wang, Wenyu; Reichl, Kyle D et al. (2018) Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones. Angew Chem Int Ed Engl 57:2101-2104
Langlais, David; Cencic, Regina; Moradin, Neda et al. (2018) Rocaglates as dual-targeting agents for experimental cerebral malaria. Proc Natl Acad Sci U S A 115:E2366-E2375
Smith, Michael J; Reichl, Kyle D; Escobar, Randolph A et al. (2018) Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. J Am Chem Soc :
Tardiff, Daniel F; Brown, Lauren E; Yan, Xiaohui et al. (2017) Dihydropyrimidine-Thiones and Clioquinol Synergize To Target ?-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. ACS Chem Neurosci 8:2039-2055
Reichl, Kyle D; Smith, Michael J; Song, Min K et al. (2017) Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade. J Am Chem Soc 139:14053-14056
Wang, Wenyu; Clay, Anthony; Krishnan, Retheesh et al. (2017) Total Syntheses of the Isomeric Aglain Natural Products Foveoglin?A and Perviridisin?B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition. Angew Chem Int Ed Engl 56:14479-14482
Manier, Salomon; Huynh, Daisy; Shen, Yu J et al. (2017) Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med 9:
Chin, Hang Gyeong; Ponnaluri, V K Chaithanya; Zhang, Guoqiang et al. (2016) Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression. Oncotarget 7:83627-83640

Showing the most recent 10 out of 22 publications