This application proposes the renewal of """"""""The National Center for Muscle Rehabilitation Research"""""""" at the University of California, San Diego. The proposal consists of five core units that span three departmental boundaries and two schools within the University. The five cores are Muscle Histology, Muscle Biomechanics, Muscle Imaging, Muscle Metabolism and Program Administration. The program is structured to foster cooperation and synergy across cores. This organization will facilitate interaction among program faculty and minimize the overhead needed to accomplish Rehabilitation Research. In addition to research cores, the program will advertise state-of-the-art workshops regarding muscle structure, function, and imaging appropriate for the Rehabilitation professional. The PIs anticipate tremendous interest by the Rehabilitation community since functional restoration by Rehabilitation is based on a healthy muscular system - muscle comprising so much of normal body mass. Collaborative opportunities are proposed for visiting Rehabilitation professionals that will match interests with one or more of the core labs in order to leverage the technologies available at the UCSD campus on behalf of the Rehabilitation professional. Finally, a program of pilot grants for both intramural and extramural applications is proposed to encourage young faculty in the formative stage of their careers to take advantage of the state-of-the-art research facilities and beautiful living conditions in La Jolla. The Medical Rehabilitation Research Infrastructure Program in Muscle at UCSD will leverage the tremendous scientific expertise available at UCSD for the benefit of the Rehabilitation professional in the short term and for the benefit of their patients in the long-term.

Public Health Relevance

Much of the practice of rehabilitation is focused on attaining muscular health. This Infrastructure program will provide discovery and educational opportunities to rehabilitation professionals regarding skeletal muscle structure, function, adaptation, imaging and disease. This program will leverage the tremendous clinical and scientific expertise at the University of California, San Diego.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Resource-Related Research Projects (R24)
Project #
2R24HD050837-06
Application #
7946068
Study Section
Special Emphasis Panel (ZHD1-RRG-K (13))
Program Officer
Nitkin, Ralph M
Project Start
2005-09-15
Project End
2015-05-31
Budget Start
2010-08-01
Budget End
2011-05-31
Support Year
6
Fiscal Year
2010
Total Cost
$849,514
Indirect Cost
Name
University of California San Diego
Department
Orthopedics
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Taylor, Andrea B; Terhune, Claire E; Toler, Maxx et al. (2018) Jaw-Muscle Fiber Architecture and Leverage in the Hard-Object Feeding Sooty Mangabey are not Structured to Facilitate Relatively Large Bite Forces Compared to Other Papionins. Anat Rec (Hoboken) 301:325-342
Huq, Emranul; Taylor, Andrea B; Su, Zuowei et al. (2018) Fiber type composition of epaxial muscles is geared toward facilitating rapid spinal extension in the leaper Galago senegalensis. Am J Phys Anthropol 166:95-106
Son, Jongsang; Indresano, Andy; Sheppard, Kristin et al. (2018) Intraoperative and biomechanical studies of human vastus lateralis and vastus medialis sarcomere length operating range. J Biomech 67:91-97
Tuttle, Lori J; Bittel, Daniel C; Bittel, Adam J et al. (2018) Early-Onset Physical Frailty in Adults With Diabesity and Peripheral Neuropathy. Can J Diabetes 42:478-483
Tirrell, Timothy F; Rademaker, Alfred W; Lieber, Richard L (2018) Analysis of hierarchical biomechanical data structures using mixed-effects models. J Biomech 69:34-39
Ward, Samuel R; Minamoto, Viviane B; Suzuki, Kentaro P et al. (2018) Recovery of rat muscle size but not function more than 1 year after a single botulinum toxin injection. Muscle Nerve 57:435-441
Meyer, Gretchen; Lieber, Richard L (2018) Muscle fibers bear a larger fraction of passive muscle tension in frogs compared with mice. J Exp Biol 221:
Oliveira, Eduardo A; Mak, Robert H (2018) Progression of chronic kidney disease in children - role of glomerular hemodynamics and interstitial fibrosis. Curr Opin Pediatr 30:220-227
Panagiotopoulou, Olga; Iriarte-Diaz, José; Wilshin, Simon et al. (2017) In vivo bone strain and finite element modeling of a rhesus macaque mandible during mastication. Zoology (Jena) 124:13-29
Jordan, Sabine D; Kriebs, Anna; Vaughan, Megan et al. (2017) CRY1/2 Selectively Repress PPAR? and Limit Exercise Capacity. Cell Metab 26:243-255.e6

Showing the most recent 10 out of 140 publications