This is an application to develop a research infrastructure support program in a psychiatry department that is emphasizing clinical excellence and clinical research. Over the past 5 years the Department has made a transition from a group practice model to an academic one, emphasizing recruiting well trained clinical investigators at the start of their careers, and has increased its annual extramural funding from less than $100,000 to well over $1 million. Institutional commitments to the Department have included doubling of its inpatient and academic space. financial resources to recruit 18 new faculty since 1987, and additional commitments sufficient to add another 15 to 20 faculty over the next 5 years. The theme of this application is behavioral problems commonly seen in general medical settings, and consists of a core and 5 pilot studies, which were selected from a group of 10 proposals after extensive review by an Intramural Advisory Committee (IAC). Core elements besides the IAC include biostatistical and data management services, a research registry for subject recruitment, shared research personnel (specifically a research nurse and 2 technicians), a biweekly research seminar, and an extramural advisory committee. The application describes a step by step plan for development of clinical investigators, beginning with identification as a general RISP investigator by producing an abstract of a research proposal, then review and critique by the IAC of a full proposal, and finally becoming a funded RISP investigator with guidance by a 4 member advisory panel to prepare the individual to become an independent investigator. Institutional resources in support of this grant include the space and financial resources noted above, laboratory space for each investigator funded by the RISP award, and an additional $300,000 in non-federal Institutional funds over the 5 year award period.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects (R24)
Project #
5R24MH051552-03
Application #
2250793
Study Section
Special Emphasis Panel (SRCM)
Project Start
1993-09-30
Project End
1998-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Kimball, James N; Rosenquist, Peter B; Dunn, Aaron et al. (2009) Prediction of antidepressant response in both 2.25xthreshold RUL and fixed high dose RUL ECT. J Affect Disord 112:85-91
Pettey, Adam A; Balkrishnan, Rajesh; Rapp, Stephen R et al. (2003) Patients with palmoplantar psoriasis have more physical disability and discomfort than patients with other forms of psoriasis: implications for clinical practice. J Am Acad Dermatol 49:271-5
McCall, W V; Reboussin, B A; Cohen, W et al. (2001) Electroconvulsive therapy is associated with superior symptomatic and functional change in depressed patients after psychiatric hospitalization. J Affect Disord 63:17-25
McCall, W V; Reboussin, B A; Rapp, S R (2001) Social support increases in the year after inpatient treatment of depression. J Psychiatr Res 35:105-10
McCall, W V; Dickerson, L A (2001) The outcome of 369 ECT consultations. J ECT 17:50-2
Denton, W H; Burleson, B R; Hobbs, B V et al. (2001) Cardiovascular reactivity and initiate/avoid patterns of marital communication: a test of Gottman's psychophysiologic model of marital interaction. J Behav Med 24:401-21
Rapp, S R; Cottrell, C A; Leary, M R (2001) Social coping strategies associated with quality of life decrements among psoriasis patients. Br J Dermatol 145:610-6
McCall, W V; Reboussin, D M; Weiner, R D et al. (2000) Titrated moderately suprathreshold vs fixed high-dose right unilateral electroconvulsive therapy: acute antidepressant and cognitive effects. Arch Gen Psychiatry 57:438-44
McCall, W V; Reboussin, B A; Cohen, W (2000) Subjective measurement of insomnia and quality of life in depressed inpatients. J Sleep Res 9:43-8
McCall, W V; Cohen, W; Reboussin, B et al. (1999) Effects of mood and age on quality of life in depressed inpatients. J Affect Disord 55:107-14

Showing the most recent 10 out of 27 publications