The neural signature of abnormal controlled processing in schizophrenia must be written into the electrical activity of cerebral neurons. A nonhuman primate model of controlled processing can serve as a bridge linking minute physiological events in cortical neurons to patterns of altered cognitive control that are indicative of cognitive deficits in schizophrenia. The first step in the proposed translational endeavor is to develop tasks for cross-species studies. We will implement a spatial working memory task developed in the context of single-cell recordings in nonhuman primates, and a sustained visual attention task used to reveal reliable vigilance deficits in schizophrenia patients and their first-degree relatives, to study visual controlled processes in schizophrenia patients, control subjects, and nonhuman primates. Through behavioral studies we will identify characteristics of spatial working memory and sustained visual attention tasks that allow for study of specific visual controlled processing deficits in schizophrenia. Next, we will identify candidate neural signals associated with visual controlled processing through the use of functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG). We will require candidate neurophysiological signals characterized by fMRI or MEG to exhibit dependency on the amount of controlled processing performed, selective synchrony between prefrontal cortex and visual stream activity, and associations with augmented sensory activity and controlled processing deficits in schizophrenia. From the results of these studies we will design a task that allows for clear delineation of neural mechanims underlying visual controlled processing in humans and nonhuman primates, and apply the task in future studies of schizophrenia. We hypothesize that high frequency neural activity (gamma) serves as a neurophysiological signal of activity in cortical networks mediating visual controlled processing. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects (R24)
Project #
5R24MH069675-02
Application #
6909980
Study Section
Special Emphasis Panel (ZMH1-NRB-Q (06))
Program Officer
Meinecke, Douglas L
Project Start
2004-07-01
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$303,526
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychiatry
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Kang, Seung Suk; MacDonald 3rd, Angus W; Chafee, Matthew V et al. (2018) Abnormal cortical neural synchrony during working memory in schizophrenia. Clin Neurophysiol 129:210-221
Hayrynen, Lauren K; Hamm, Jordan P; Sponheim, Scott R et al. (2016) Frequency-specific disruptions of neuronal oscillations reveal aberrant auditory processing in schizophrenia. Psychophysiology 53:786-95
Docherty, Anna R; Sponheim, Scott R; Kerns, John G (2015) Self-reported affective traits and current affective experiences of biological relatives of people with schizophrenia. Schizophr Res 161:340-4
Elshaikh, Ansam A; Sponheim, Scott R; Chafee, Matt V et al. (2015) Spatial attentional control is not impaired in schizophrenia: Dissociating specific deficits from generalized impairments. J Abnorm Psychol 124:302-308
Wilson, Sylia; Sponheim, Scott R (2014) Dimensions underlying psychotic and manic symptomatology: Extending normal-range personality traits to schizophrenia and bipolar spectra. Compr Psychiatry 55:1809-19
Lawlor-Savage, Linette; Sponheim, Scott R; Goghari, Vina M (2014) Impaired recognition of happy facial expressions in bipolar disorder. Acta Neuropsychiatr 26:253-9
Docherty, Anna R; Sponheim, Scott R; Gizer, Ian R (2014) DISC1 loci not associated with anhedonia in individuals with genetic liability for schizophrenia. Psychiatr Genet 24:120-1
Docherty, Anna R; Sponheim, Scott R; Kerns, John G (2014) Further examination of ambivalence in relation to the schizophrenia spectrum. Schizophr Res 158:261-3
Goghari, Vina M; Macdonald 3rd, Angus W; Sponheim, Scott R (2014) Relationship between prefrontal gray matter volumes and working memory performance in schizophrenia: a family study. Schizophr Res 153:113-21
Crowe, David A; Goodwin, Shikha J; Blackman, Rachael K et al. (2013) Prefrontal neurons transmit signals to parietal neurons that reflect executive control of cognition. Nat Neurosci 16:1484-91

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